V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 1-100) antibody

Antigen: V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN)

Synonyms: Yes, c-yes, HsT441, P61-YES, yes, LYN, YES1, hst441, p61-yes, MGC89200, JTK8, FLJ26625, Hck-2, AA407514, lyn

Epitope: AA 1-100

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN373594

Additional Information

Characteristics: Synonyms: Tyrosine-protein kinase Lyn

Alternative name: LYN

Gene ID: 4067

Swiss-Prot: P07948

Immunogen: Recombinant protein encoding aa 1-100 of human Lyn

Cross-Reactivity: Human

Description: Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK)mostly expressed in hemopoietic cells, which is important in cellular signaling. It containsan SH2 and SH3 domain and has been found to be cleaved after activation of caspases inapoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn whichplays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signalingpathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregationand can also phosphorylate Tec on multiple residues.

Specificity: This antibody detects Lyn at aa 1-100. Species: Human. Others not tested. Add. Information: Molecular weight: 53/56kDaCellular localisation: Membrane associated

Application Details

Application Notes: Western blot: 2-4 µg/ml for 2 hrs at RT. Positive control: HeLa cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.2 mg/ml

Purification: Purified

Buffer: 10 mM PBS, pH 7.4 with BSA and Sodium Azide

Storage: Store the antibody (undiluted) at 2 – 8 °C. Shelf life: One year from despatch.

Restrictions: For Research Use only