SMAD, Mothers Against DPP Homolog 2 (SMAD2) (Internal Region) antibody

Details for Product No. ABIN374102
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Antigen
Synonyms jv18, Xmad2, madh2, madr2, XSmad2, hmad-2, hsmad2, jv18-1, smad-2, fj43c06, wu:fj43c06, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2, 7120426M23Rik, Madh2, Madr2, Smad-2, mMad2
Epitope
Internal Region
(40), (36), (33), (22), (21), (17), (14), (13), (13), (12), (8), (7), (7), (6), (5), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human
(334), (192), (186), (78), (75), (65), (13), (3), (1), (1), (1), (1)
Host
Goat
(295), (35), (11)
Clonality
Polyclonal
Conjugate
Un-conjugated
(12), (10), (10), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (4), (2)
Application
ELISA, Western Blotting (WB)
(261), (140), (64), (61), (60), (48), (35), (18), (10), (6), (5), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374102
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Immunogen Peptide from the internal region of the protein sequence according to NP_005892.1. Genename: SMAD2
Sequence EIWGLSTPNT IDC
Specificity This antibody detects SMAD2 (Internal). Species Reactivity: Tested: Human. Expected from sequence similarity: Cow.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Alternative Name SMAD2
Background SMAD2 (Mothers against decapentaplegic homolog 2) belongs to the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated Smad2 is then able to form a complex with Smad4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression.
Alternate names: JV18-1, MAD homolog 2, MADH2, MADR2, Mad-related protein 2, Mothers against DPP homolog 2, Mothers against decapentaplegic homolog 2, SMAD 2, SMAD family member 2, SMAD-2
Gene ID 4087
NCBI Accession NP_005892
UniProt Q15796
Research Area Signaling, Transcription Factors
Application Notes Peptide ELISA: Limit dilution 1: 4000. Western blot: 1-3 µg/ml. Approx 45kDa and 50kDa bands seen in HeLa cell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preserative and 0.5% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (Internal Region) antibody anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (Internal Region) antibody
Background publications Eppert, Scherer, Ozcelik et al.: "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma." in: Cell, Vol. 86, Issue 4, pp. 543-52, 1996 (PubMed).

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