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DKK2 antibody (Dickkopf 2 Homolog (Xenopus Laevis)) (C-Term)

Details for Product anti-DKK2 Antibody No. ABIN374181, Supplier: Log in to see
Antigen
  • DKK-2
  • Dkk4
Alternatives
anti-Human DKK2 antibody for ELISA
Epitope
C-Term
24
12
5
5
4
2
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
61
21
10
2
2
1
Host
Goat
54
14
Clonality
Polyclonal
Conjugate
This DKK2 antibody is un-conjugated
6
5
4
3
3
3
Application
Western Blotting (WB)
53
37
15
9
2
1
1
1
Supplier
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Immunogen Peptide with sequence ATYSSKARLHVCQKI, from the C Terminus of the protein sequence Genename: DKK2
Specificity This antibody detects Dickkopf-2 at C-term.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name Dickkopf-2 (DKK2) (DKK2 Antibody Abstract)
Background Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.Synonyms: Dickkopf-related protein 2, Dkk-2
Gene ID 27123
NCBI Accession NP_055236
UniProt Q9UBU2
Pathways WNT Signaling
Application Notes Peptide ELISA: 1/8000. Western blot: 1 - 3 μg/mL. Approx 28 kDa band observed in Human Heart lysate (calculatedMW of 28.8 kDa according to NP_055236).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-DKK2 antibody (Dickkopf 2 Homolog (Xenopus Laevis)) (C-Term) (ABIN374181) anti-Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) (C-Term) antibody
Background publications Krupnik, Sharp, Jiang, Robison, Chickering, Amaravadi, Brown, Guyot, Mays, Leiby, Chang, Duong, Goodearl, Gearing, Sokol, McCarthy: "Functional and structural diversity of the human Dickkopf gene family." in: Gene, Vol. 238, Issue 2, pp. 301-13, 1999