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Enhancer of Zeste Homolog 1 (Drosophila) (EZH1) (N-Term) antibody

Details for Product No. ABIN374284, Supplier: Login to see
Antigen
  • EZH1
  • KMT6B
  • AW557915
  • mKIAA0388
  • si:ch211-250i3.1
  • zgc:136829
  • enx-1
  • enx1
  • ezh1
  • ezh2
  • kmt6
  • xez
Epitope
N-Term
26
18
11
3
2
1
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine)
94
46
35
6
3
2
1
1
1
1
1
1
Host
Goat
80
16
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
78
49
34
14
11
11
4
2
1
1
1
1
Supplier
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Immunogen Peptide from N Terminus of the protein sequence according to NP_001982.2 Genename: EZH1
Sequence EIPNPPTSKC ITY
Specificity This antibody detects EZH1 at N-term.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, CowSpecies reactivity (tested):Human
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name EZH1 (EZH1 Antibody Abstract)
Background EZH1 is a human homolog of the Drosophila gene Enhancer of zeste E(z), a member of the polycomb group of transcriptional repressors. In mice, EZH1 is a regulator of homeotic gene expression implicated in the assembly of repressive protein complexes in chromatin. The strong sequence conservation between species suggests potential role for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that stably maintain heterochromatin.Synonyms: ENX-2, Enhancer of zeste homolog 1, Histone-lysine N-methyltransferase EZH1, KIAA0388
Gene ID 2145
NCBI Accession NP_001982
UniProt Q92800
Research Area Chromatin and Nuclear Signaling
Pathways
Application Notes Peptide ELISA: Limit dilution 1: 32000. Western blot: 1-3 μg/mL. Approx 75-80 kDa band seen in MOLT-4 lysate [Predicted MW of80 kDa according to NP_001982].
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH 7.3, 0.02 % sodium azide, 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Enhancer of Zeste Homolog 1 (Drosophila) (EZH1) (N-Term) antibody (ABIN374284) anti-Enhancer of Zeste Homolog 1 (Drosophila) (EZH1) (N-Term) antibody
Background publications Abel, Brody, Valdes et al.: "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1." in: Genomics, Vol. 37, Issue 2, pp. 161-71, 1997 (PubMed).