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GOPC antibody (C-Term)

GOPC Reactivity: Human, Cow, Dog WB, IF Host: Goat Polyclonal unconjugated
Catalog No. ABIN374395
  • Target See all GOPC Antibodies
    GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))
    Binding Specificity
    • 15
    • 11
    • 7
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 82
    • 33
    • 10
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Cow, Dog
    Host
    • 81
    • 1
    Goat
    Clonality
    • 73
    • 9
    Polyclonal
    Conjugate
    • 29
    • 8
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GOPC antibody is un-conjugated
    Application
    • 44
    • 30
    • 30
    • 14
    • 14
    • 11
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    C-LDDLHTLYHK KSY
    Specificity
    This antibody detects PIST / FIG / GOPC at C-term. It is expected to recognize both reported isoforms.
    Cross-Reactivity (Details)
    Species reactivity (expected):Canine (Dog), Cow.
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide from C-Terminus of the protein sequence according to NP_065132.1, NP_001017408.1 Genename: GOPC
    Top Product
    Discover our top product GOPC Primary Antibody
  • Application Notes
    Peptide ELISA: Limit dilution 1: 128000. Western blot: 0.05-0.2 μg/mL. Approx.55 kDa band observed in Human Brain (FrontalCortex) lysates (calculated MW of 50.5 kDa according to NP_065132.1).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))
    Alternative Name
    GOPC / PIST (GOPC Products)
    Synonyms
    DKFZp459H2130 antibody, 2210402P09Rik antibody, AI844555 antibody, CAL antibody, FIG antibody, GOPC1 antibody, PIST antibody, fe38f01 antibody, wu:fe38f01 antibody, zgc:56254 antibody, zgc:65853 antibody, dJ94G16.2 antibody, cal antibody, gopc1 antibody, pist antibody, golgi associated PDZ and coiled-coil motif containing antibody, golgi-associated PDZ and coiled-coil motif containing antibody, golgi-associated PDZ and coiled-coil motif containing S homeolog antibody, GOPC antibody, Gopc antibody, gopc antibody, gopc.S antibody
    Background
    PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner. PIST, a PDZ domain-containing Golgi protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6. Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1.Synonyms: CAL, CFTR-associated ligand, FIG, Fused in glioblastoma, Golgi-associated PDZ and coiled-coil motif-containing protein, PDZ protein interacting specifically with TC10
    Gene ID
    57120
    NCBI Accession
    NP_065132
    UniProt
    Q9HD26
    Pathways
    Maintenance of Protein Location, Asymmetric Protein Localization
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