HPS3 antibody (C-Term)

Catalog No. ABIN374450

Product Details anti-HPS3 Antibody

Target: HPS3 (Hermansky-Pudlak Syndrome 3 (HPS3))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This HPS3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PYLLYCSRKK PLT

Specificity: This antibody recognizes HPS3/Cocoa

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide from the C Terminus of the protein sequence according to NP_115759

Application Details

Application Notes: Peptide ELISA: > 1/32,000. Western Blot: 1-3 μg/mL. Detects a band of Approx 110 kDa in A431 cell lysate(Predicted Molecular Weight: 114 kDa).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for HPS3

Target: HPS3 (Hermansky-Pudlak Syndrome 3 (HPS3))

Alternative Name: HPS3 (HPS3 Products)

Synonyms: SUTAL antibody, HPS3 antibody, coa antibody, HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 antibody, HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 L homeolog antibody, Hermansky-Pudlak syndrome 3 antibody, HPS3 antibody, hps3.L antibody, Hps3 antibody

Background: HPS3 is involved in early stages of melanosome biogenesis and maturation. Defects in HPS3 are the cause of the cocoa (coa) mutant, and of Hermansky-Pudlak syndrome type 3 (HPS3). HPS3 is an autosomal recessive disorder, characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.Synonyms: Hermansky-Pudlak syndrome 3

Gene ID: 84343

NCBI Accession: NP_115759

UniProt: Q969F9