Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody

Details for Product No. ABIN374456
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Antigen
Synonyms API4, EPR-1, AP14, bir5a, survivin, LOC398389, BIRC5, BIR1, Su2, Survivin, Survivin1, XBIR1, api4, epr-1, svv1, xSurvivin1, xsurv, SIX, Su1, svv2, birc5, xSurvivin, xSurvivin2
Epitope
C-Term
(21), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(67), (26), (8), (1), (1), (1), (1)
Host
Goat
(69), (14), (1)
Clonality
Polyclonal
Application
Western Blotting (WB)
(67), (23), (22), (17), (15), (12), (7), (5), (4), (3), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN374456
Quantity 0.1 mg
Price
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Immunogen Peptide with sequence CVRRAIEQLAAMD, from the C Terminus of the protein sequence
Specificity This antibody reacts to Apoptosis inhibitor survivin.
Purification Affinity chromatography
Alternative Name IAP4 / BIRC5
Background Survivin is an anti-apoptotic protein, expressed in the G2/M cell cycle phase. At the onset of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin- microtubule interactions results in loss of survivin's anti-apoptotic function and increased caspase 3 activity. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein. Survivin might affect regulation of neural cell proliferative responses after brain injury. Survivin is also an inhibitor of apoptosis (IAP), or programmed cell death, that is selectively overexpressed in common human cancers.
Alternate names: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
Gene ID 332
NCBI Accession NP_001012270.1
UniProt O15392
Research Area Cancer, Apoptosis/Necrosis, Neurology
Application Notes Peptide ELISA: 1/16000. Western blot: 0.01 - 0.5 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody
Background publications Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

Hosts (69), (14), (1)
Reactivities (67), (26), (8), (1), (1), (1), (1)
Applications (67), (23), (22), (17), (15), (12), (7), (5), (4), (3), (1), (1), (1), (1), (1)
Epitopes (21), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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