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anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody

Details for Product No. ABIN374464, Supplier: Log in to see
Antigen
  • ANTXR1
  • ATR
  • TEM8
  • 2310008J16Rik
  • 2810405N18Rik
  • Antrx1
  • Tem8
  • anthrax toxin receptor 1
  • ANTXR1
  • LOC100357637
  • Antxr1
Epitope
C-Term
28
24
14
13
6
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
175
63
59
4
3
3
3
3
2
2
2
1
1
Host
Goat
137
24
17
Clonality
Polyclonal
Conjugate
Un-conjugated
10
10
10
9
7
7
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
102
79
50
36
34
26
22
22
14
5
1
1
Options
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Immunogen Peptide with sequence C-RAPPPSRPPPRPSV, from the C Terminus of the protein sequence
Specificity This antibody reacts to Anthrax toxin receptor 1.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Bovine, Canine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name Anthrax Toxin Receptor 1 (ANTXR1 Antibody Abstract)
Background TEM8 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has also been shown to be a docking protein or receptor for Bacillus anthracistoxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor(EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.Synonyms: ANTXR1, ATR, TEM8, Tumor endothelial marker 8
Gene ID 84168, 9606
UniProt Q9H6X2
Research Area Toxicology, Receptors
Application Notes Peptide ELISA: 1/64000. Western blot: 0.2 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody (ABIN374464) anti-anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody
Background publications Carson-Walter, Watkins, Nanda, Vogelstein, Kinzler, St Croix: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Cross, Lindsey, Fantes, McKay, McGill, Cooke: "The structure of a subterminal repeated sequence present on many human chromosomes." in: Nucleic acids research, Vol. 18, Issue 22, pp. 6649-57, 1991 (PubMed).