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HSD17B10 antibody (Hydroxysteroid (17-Beta) Dehydrogenase 10) (C-Term)

Details for Product anti-HSD17B10 Antibody No. ABIN374505, Supplier: Log in to see
Antigen
  • 17b-HSD10
  • 17bHSD10
  • ABAD
  • abad
  • Ads9
  • CAMR
  • camr
  • DUPXp11.22
  • ERAB
  • erab
  • Hadh2
  • hadh2
  • HADH2
  • hcd2
  • HCD2
  • hsd10
  • HSD17B10
  • im:6899159
  • mhbd
  • MHBD
  • mrpp2
  • MRPP2
  • MRX17
  • mrx17
  • mrx31
  • MRX31
  • mrxs10
  • MRXS10
  • schad
  • SCHAD
  • sdr5c1
  • SDR5C1
  • wu:fj61f03
  • zgc:101605
Epitope
C-Term
20
7
5
5
4
3
3
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Monkey, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
103
34
32
5
4
2
2
1
1
1
1
1
Host
Goat
77
18
15
1
Clonality
Polyclonal
Conjugate
This HSD17B10 antibody is un-conjugated
3
3
3
1
1
1
Application
Western Blotting (WB)
96
40
33
23
21
12
5
1
1
1
1
Supplier
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Immunogen Peptide with sequence CIRLDGAIRMQP, from the C Terminus of the protein sequence
Specificity This antibody reacts to HSD17B10.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name HSD17B10 / ERAB (HSD17B10 Antibody Abstract)
Background ERAB is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. It has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD, a disorder characterized by neurological abnormalities, including psychomotor retardation and loss of mental and motor skills). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. Abundant in human liver, kidney and gonads, but it is present in only negligible amounts in skeletal muscle. At the sub-cellular level, in normal tissues, this protein is located in mithocondria. It is over-expressed in Neurons of patients with Alzheimer's disease.Synonyms: 17-beta-HSD10, 17-beta-hydroxysteroid dehydrogenase 10, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type II, 3-hydroxyacyl-CoA dehydrogenase type-2, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, HADH2, MRPP2, Mitochondrial Marker, Mitochondrial ribonuclease P protein 2, SCHAD, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, XH98G2
Gene ID 3028, 9606
UniProt Q99714
Research Area Hormones, Receptors
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.3 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-HSD17B10 antibody (Hydroxysteroid (17-Beta) Dehydrogenase 10) (C-Term) (ABIN374505) anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term) antibody
Background publications He, Schulz, Yang: "A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10741-6, 1998 (PubMed).