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A Kinase (PRKA) Anchor Protein (Yotiao) 9 (AKAP9) (C-Term) antibody

Details for Product No. ABIN374523
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Antigen
Synonyms
AKAP9, HYPERION, wu:fj02h02, prka9, yotiao, akap350, akap450, hyperion, AKAP-9, AKAP350, AKAP450, CG-NAP, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO, 5730481H23Rik, AW545847, C79026, mKIAA0803, Gisp ... show more
AKAP9, HYPERION, wu:fj02h02, prka9, yotiao, akap350, akap450, hyperion, AKAP-9, AKAP350, AKAP450, CG-NAP, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO, 5730481H23Rik, AW545847, C79026, mKIAA0803, Gisp, Yotiao, AKAP120 show less
Epitope
C-Term
(5), (4), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(18), (2), (1), (1), (1)
Host
Goat
(9), (6), (3)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(15), (10), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN374523
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Immunogen Peptide with sequence C-SGSTTQFHAGMR, from the C Terminus of the protein sequence
Specificity This antibody reacts to AKAP9. This antibody is expected to recognise isoforms 2 and 3. The isoforms Yotiao, AKAP350B and AKAP350C are not recognized. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse.
Purification Affinity chromatography
Alternative Name AKAP9
Background AKAP9 is a novel cytoskeletal protein specifically concentrated in the neuromuscular junction and neuronal synapes that interacts with specific splice variants of NMDA Receptor Subunit NR1 in a C1 exon cassette dependent manner. It has also been shown to physically attach the type I protein phosphatase (PP1) and the adenosine 3',5'-mono- phosphate (cAMP) dependent protein kinase (PKA) holoenzyme to NMDA receptors to regulate channel activity. NMDA receptors are involved with many important functions and dysfunctions of the nervous system, including synapse formation, synaptic plasticity, and excitotoxicity. AKAP9 research may lead to a clearer understanding of these neural processes by explaining how NMDA receptors are targeted to particular synapses, how this localization is regulated during development and synaptic activity, and how NMDA receptor activity is transduced into intracellular signals responsible for particular neuronal responses.
Alternate names: A-kinase anchor protein 350 kDa, A-kinase anchor protein 450 kDa, A-kinase anchor protein 9, AKAP120-like protein, AKAP350, AKAP450, KIAA0803, Protein hyperion, Protein kinase A-anchoring protein 9, Protein yotiao, entrosome- and Golgi-localized PKN- associated protein
Gene ID 10142
NCBI Accession 9606
UniProt Q99996
Application Notes Peptide ELISA: 1/32000. Western Blot: 1 - 3 µg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Ciampi, Knauf, Kerler et al.: "Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer." in: The Journal of clinical investigation, Vol. 115, Issue 1, pp. 94-101, 2005 (PubMed).

Validation Images
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