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MYD88 antibody (Internal Region)

MYD88 Reactivity: Human, Mouse, Rat, Dog, Chimpanzee WB, IHC (p), EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN374527
  • Target See all MYD88 Antibodies
    MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
    Binding Specificity
    • 15
    • 8
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 98
    • 63
    • 50
    • 16
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Chimpanzee
    Host
    • 92
    • 11
    • 2
    Goat
    Clonality
    • 84
    • 21
    Polyclonal
    Conjugate
    • 65
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MYD88 antibody is un-conjugated
    Application
    • 86
    • 32
    • 22
    • 18
    • 16
    • 14
    • 13
    • 13
    • 11
    • 10
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Sequence
    C-IKYKAMKKEF P
    Specificity
    This antibody recognizes MYD88 (Internal).
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat and Canine (Dog).
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
    Immunogen
    Peptide with sequence from the internal region of the protein sequence according to NP_002459.1. Genename: MYD88
    Top Product
    Discover our top product MYD88 Primary Antibody
  • Application Notes
    Peptide ELISA: Limit Dilution: 1/16000. Western blot: 0.03-0.1 μg/mL. Approx 33 kDa band observed in HumanThymus lysates(calculated MW of 33.3 kDa according to NP_002459.1). Immunohistochemistry: 2-5 μg/mL. In paraffin embedded tonsil, stains clusters of cells some of which are likely to be plasmacells. In the interfollicular area occasional strongly stained areas. Epithelium is weaklypositive.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
    Alternative Name
    MYD88 (MYD88 Products)
    Synonyms
    MYD88D antibody, XMyD88 antibody, myd88d antibody, MGC84928 antibody, CG2078 antibody, DMMYD88 antibody, DmMyD88 antibody, DmMyd88 antibody, Dmel\\CG2078 antibody, EP(2)2535 antibody, Kra antibody, LD20892 antibody, MYD88 antibody, MyD88 antibody, Myd88F antibody, dMyD88 antibody, dMyd88 antibody, kra antibody, myd88 antibody, zgc:103541 antibody, GB12344 antibody, NV10640 antibody, myd88-a antibody, myd88-b antibody, myeloid differentiation primary response 88 antibody, myeloid differentiation primary response 88 S homeolog antibody, myeloid differentiation primary response gene 88 antibody, CG2078 gene product from transcript CG2078-RB antibody, myeloid differentiation primary response protein MyD88-A antibody, myeloid differentiation primary response protein MyD88 antibody, myeloid differentiation factor 88 antibody, myeloid differentiation primary response 88 L homeolog antibody, MYD88 antibody, myd88.S antibody, Myd88 antibody, myd88 antibody, LOC413194 antibody, LOC100118553 antibody, LOC575153 antibody, myd88.L antibody
    Background
    Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL1R and is involved in the inflammatory response induced by IL1, IL18 and LPS. MyD88 associates with and recruits IRAK to IL1 receptor complex in response to IL1. This pathway further leads to activation of NFkB. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL1 and IL18, and MyD88 deficient mice lack responses to bacterial product LPS that employs Toll like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 has a wide tissue distribution.Synonyms: Myeloid differentiation primary response protein MyD88
    Gene ID
    4615, 9606
    UniProt
    Q99836
    Pathways
    NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
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