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DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) (C-Term) antibody

Details for Product No. ABIN374653, Supplier: Log in to see
Antigen
  • DCP1A
  • 1110066A22Rik
  • 4930568L04Rik
  • AU019772
  • D14Ertd817e
  • Mitc1
  • SMIF
  • RGD1561298
  • mitc1
  • HSA275986
  • Nbla00360
  • SMAD4IP1
  • smad4ip1
  • smif
Epitope
C-Term
20
15
13
5
5
4
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
80
22
7
4
4
1
1
1
1
1
Host
Goat
52
14
14
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
1
Application
Western Blotting (WB)
71
51
9
6
6
1
1
1
1
Supplier
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Immunogen Peptide with sequence C-QVLTKNKDNHN, from the C Terminus of the protein sequence
Specificity This antibody reacts to DCP1A.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name DCP1A (DCP1A Antibody Abstract)
Background Dcp1a is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Dcp1a binds DCP1B, DCP2, RENT1 and SMAD4 and forms part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1.Synonyms: SMIF, Smad4-interacting transcriptional co-activator, Transcription factor SMIF, mRNA-decapping enzyme 1A
Gene ID 55802, 9606
UniProt Q9NPI6
Application Notes Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) (C-Term) antibody (ABIN374653) anti-DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) (C-Term) antibody
Background publications Cougot, Babajko, Séraphin: "Cytoplasmic foci are sites of mRNA decay in human cells." in: The Journal of cell biology, Vol. 165, Issue 1, pp. 31-40, 2004 (PubMed).