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CDX2 antibody (Caudal Type Homeobox 2) (Internal Region)

Details for Product anti-CDX2 Antibody No. ABIN374665, Supplier: Log in to see
Antigen
  • CDX2
  • MGC130987
  • cdx3-like
  • CDX-3
  • CDX3
  • CDX-2
  • Cdx-2
  • caudal type homeobox 2
  • caudal type homeo box 2
  • CDX2
  • cdx2
  • Cdx2
Alternatives
anti-Human CDX2 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
Internal Region
24
18
17
15
14
14
14
9
8
7
5
5
5
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
243
75
72
11
11
8
6
4
4
4
3
3
3
2
1
Host
Goat
150
75
20
Clonality
Polyclonal
Conjugate
This CDX2 antibody is un-conjugated
11
8
8
6
5
5
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
146
106
72
59
51
36
31
20
19
13
3
3
2
2
1
Options
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Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_001256.1. Genename: CDX2
Sequence EQLSPGGQRR NLCE
Specificity This antibody recognizes CDX2. No cross-reactivity expected with CDX1 and 4.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.
Purification Affinity Chromatography
Alternative Name Cdx2 (CDX2 Antibody Abstract)
Background CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20.Synonyms: CDX-3, CDX3, Caudal-type homeobox protein 2, Homeobox protein CDX-2
Gene ID 1045
NCBI Accession NP_001256
UniProt Q99626
Pathways Peptide Hormone Metabolism, Stem Cell Maintenance
Application Notes Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % Sodium Azide, pH 7.3 with 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-CDX2 antibody (Caudal Type Homeobox 2) (Internal Region) (ABIN374665) anti-Caudal Type Homeobox 2 (CDX2) (Internal Region) antibody
Background publications Wells, Melton: "Vertebrate endoderm development." in: Annual review of cell and developmental biology, Vol. 15, pp. 393-410, 2000 (PubMed).