HSD11B1 antibody (C-Term)

Catalog No. ABIN374673

Product Details anti-HSD11B1 Antibody

Target: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This HSD11B1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to HSD3B1.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-DRHKETLKSKTQ, from the C Terminus of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/128000. Western Blot: 0.01 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HSD11B1

Target: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Alternative Name: 3-beta-HSD1 / HSD3B1 (HSD11B1 Products)

Synonyms: 11-DH antibody, 11-beta-HSD1 antibody, CORTRD2 antibody, HDL antibody, HSD11 antibody, HSD11B antibody, HSD11L antibody, SDR26C1 antibody, hsd11 antibody, hsd11b antibody, LRRGT00065 antibody, hydroxysteroid 11-beta dehydrogenase 1 antibody, hydroxysteroid (11-beta) dehydrogenase 1b antibody, hydroxysteroid (11-beta) dehydrogenase 1 L homeolog antibody, HSD11B1 antibody, HSD11B1b antibody, hsd11b1.L antibody, Hsd11b1 antibody

Background: HSD3B1 (3-beta hydroxysteroid dehydrogenase) is a bifunctional enzyme that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. There are two HSD3B1 proteins, type I and type II. Expressed by different genes, they function in different areas of the body. HSD3B1 has been shown to be a highly specific and sensitive trophoblast-associated marker (Mao et. al).Synonyms: 3-beta-hydroxysteroid dehydrogenase, Delta 5-->4-isomerase type 1, Trophoblast Marker

Gene ID: 3283

NCBI Accession: NP_000853

UniProt: P14060

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process