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Unc-13 Homolog D (C. Elegans) (UNC13D) (Internal Region) antibody

Details for Product No. ABIN374716, Supplier: Log in to see
Antigen
  • UNC13D
  • FHL3
  • HLH3
  • HPLH3
  • Munc13-4
  • 2610108D09Rik
  • Jinx
  • mFLJ00067
  • Unc13h4
Epitope
Internal Region
22
8
4
4
3
3
2
2
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
50
9
6
4
4
4
2
2
1
Host
Goat
28
15
9
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
41
30
14
9
4
2
1
1
1
1
Supplier
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Immunogen Peptide with sequence C-ETQKHKKDLHPLFD, from the internal region of the protein sequence
Specificity This antibody reacts to Munc13-4 / UNC13D.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name UNC13D (UNC13D Antibody Abstract)
Background Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Munc 13-4 localises with cytotoxic granules at the immunologic synapse. Munc 13-4 is essential for the priming step of cytolytic granule secretion preceding vesicle membrane fusion. There are two named isoforms.Synonyms: Munc13-4, Protein unc-13 homolog D
Gene ID 201294, 9606
UniProt Q70J99
Pathways
Application Notes ELISA: 1/128000. Western Blot: 1 - 3 μg/mL. Immunohistochemistry on paraffin sections: 2.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Unc-13 Homolog D (C. Elegans) (UNC13D) (Internal Region) antibody (ABIN374716) anti-Unc-13 Homolog D (C. Elegans) (UNC13D) (Internal Region) antibody
 image for anti-Unc-13 Homolog D (C. Elegans) (UNC13D) (Internal Region) antibody (ABIN374716) anti-Unc-13 Homolog D (C. Elegans) (UNC13D) (Internal Region) antibody (Image 2)
Background publications Zur Stadt, Beutel, Kolberg et al.: "Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A." in: Human mutation, Vol. 27, Issue 1, pp. 62-8, 2005 (PubMed).