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Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (Internal Region) antibody

Details for Product No. ABIN374746, Supplier: Log in to see
Antigen
  • 0610025L01Rik
  • D9Bwg1161e
  • DOD
  • dod
  • OTTMUSG00000014964
  • pin1
  • Pin1-ps1
  • pin1a
  • pin1b
  • Pin1l
  • ubl5
  • UBL5
Epitope
Internal Region
30
30
27
15
15
13
11
10
7
4
4
3
3
2
2
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
183
84
77
10
8
7
6
3
2
1
1
1
Host
Goat
121
56
14
8
Clonality
Polyclonal
Conjugate
Un-conjugated
11
9
7
5
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
150
110
42
32
22
17
15
14
13
6
1
Supplier
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Immunogen Peptide with sequence C-KHSQSRRPSSWRQEKITR, from the internal region of the protein sequence
Specificity This antibody reacts to PIN1.
Cross-Reactivity (Details) Species reactivity (expected):Human, Mouse, Canine.
Species reactivity (tested):Rat.
Purification Affinity chromatography
Alternative Name PIN1 (PIN1 Antibody Abstract)
Background Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.Synonyms: PIN-1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1
Gene ID 5300
NCBI Accession NP_006212
UniProt Q13526
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.2 - 0.6 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (Internal Region) antibody (ABIN374746) anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (Internal Region) antibody
Background publications Pastorino, Sun, Lu, Zhou, Balastik, Finn, Wulf, Lim, Li, Li, Xia, Nicholson, Lu: "The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production." in: Nature, Vol. 440, Issue 7083, pp. 528-34, 2006 (PubMed).