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OGG1 antibody (8-Oxoguanine DNA Glycosylase) (Internal Region)

Details for Product anti-OGG1 Antibody No. ABIN374768, Supplier: Log in to see
Antigen
  • OGG1
  • zgc:158858
  • 8-oxoguanine-DNA glycosylase 1
  • ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1
  • ATOGG1
  • F8K7.14
  • F8K7_14
  • 19.m02329
  • DDBDRAFT_0184479
  • DDBDRAFT_0233024
  • DDB_0184479
  • DDB_0233024
  • ogg1
  • Tb04.1H19.930
  • HMMH
  • HOGG1
  • MUTM
  • OGH1
  • Mmh
Alternatives
anti-Mouse (Murine) OGG1 antibody for Western Blotting
Epitope
Internal Region
14
13
7
7
6
4
3
2
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
75
46
45
6
2
1
1
1
Host
Goat
72
18
5
Clonality
Polyclonal
Conjugate
This OGG1 antibody is un-conjugated
6
6
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
78
27
25
14
11
5
4
3
2
1
Supplier
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Immunogen Peptide with sequence C-HPKTSQAKGPSPLANK, from the internal region of the protein sequence
Specificity This antibody reacts to OGG1.
Cross-Reactivity (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Rat.
Purification Affinity chromatography
Alternative Name OGG1 (OGG1 Antibody Abstract)
Background The Ogg1 gene encodes a DNA repair enzyme (N glycosylase/DNA lyase) that incises DNA at 8 oxoG residues. N glycosylase/DNA lyase excises 7,8 dihydro 8 oxoguanine and 2,6 diamino 4 hydroxy 5 N methylformamidopyrimidine (FAPY) from damaged DNA. N glycosylase/DNA lyase has a beta lyase activity that nicks DNA 3' to the lesion. Alternative splicing of the C terminal region of the Ogg1 gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N terminal region in common. Many alternative splice variants for this gene have been described, but the full length nature for every variant has not been determined. The N terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.Synonyms: MMH, MUTM, N-glycosylase/DNA lyase, OGH1
Gene ID 4968, 9606
UniProt O15527
Pathways DNA Damage Repair
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-OGG1 antibody (8-Oxoguanine DNA Glycosylase) (Internal Region) (ABIN374768) anti-8-Oxoguanine DNA Glycosylase (OGG1) (Internal Region) antibody
Background publications Kovtun, Liu, Bjoras et al.: "OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells." in: Nature, Vol. 447, Issue 7143, pp. 447-52, 2007 (PubMed).