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PHLPP2 antibody (C-Term)

PHLPP2 Reactivity: Human WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN374772
  • Target See all PHLPP2 Antibodies
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    Binding Specificity
    • 9
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 17
    • 5
    • 2
    • 1
    • 1
    Human
    Host
    • 16
    • 1
    Goat
    Clonality
    • 17
    Polyclonal
    Conjugate
    • 17
    This PHLPP2 antibody is un-conjugated
    Application
    • 16
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Specificity
    This antibody reacts to PHLPP2.
    Purification
    Affinity chromatography
    Immunogen
    Peptide with sequence C-PHEEDRTEPPEEFD, from the C Terminus of the protein sequence
    Top Product
    Discover our top product PHLPP2 Primary Antibody
  • Application Notes
    Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    Alternative Name
    PHLPP2 (PHLPP2 Products)
    Synonyms
    PHLPPL antibody, phlppl antibody, AI481772 antibody, C130044A18Rik antibody, Phlppl antibody, RGD1562857 antibody, PH domain and leucine rich repeat protein phosphatase 2 antibody, PH domain and leucine rich repeat protein phosphatase 2 S homeolog antibody, PHLPP2 antibody, phlpp2.S antibody, phlpp2 antibody, Phlpp2 antibody
    Background
    PHLPP2 contains 21 LRR (leucine rich) repeats, 1 PH domain and 1 PP2C like domain. It is a protein phosphatase that specifically mediates dephosphorylation of AKT1 Ser 473, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro and antiapoptotic genes. Dephosphorylation of Ser 473 of AKT1 triggers apoptosis and decrease cell proliferation. PHLPP2 also controls the phosphorylation of AKT3. It binds 2 manganese ions per subunit. There are 3 named isoforms produced by alternative splicing.Synonyms: KIAA0931, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPPL
    Gene ID
    23035
    NCBI Accession
    NP_055835
    UniProt
    Q6ZVD8
    Pathways
    PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway
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