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Collagen, Type VII (COL7) (Internal Region) antibody

Details for Product No. ABIN374776, Supplier: Log in to see
Antigen
  • COL7A1
Epitope
Internal Region
13
11
7
6
4
3
2
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
40
24
17
2
2
1
1
1
1
1
1
Host
Goat
24
17
12
Clonality
Polyclonal
Conjugate
Un-conjugated
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
24
22
15
13
13
11
5
4
4
3
1
1
1
1
1
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Immunogen Peptide with sequence C-TVQYSDDPRTEF, from the internal region of the protein sequence
Specificity This antibody reacts to Collagen, type VII. This product does not work on cryostat sections of Normal Human Skin.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Human, Canine, Porcine.
Species reactivity (tested):Rat.
Purification Affinity chromatography
Alternative Name Collagen Type VII (COL7 Antibody Abstract)
Background Type VII collagen fibrils are composed of three identical alpha collagen chains. It's location is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in the collagen V11 gene are associated with all forms of dystrophic epidermolysis bullosa.Synonyms: COL7A1, LC collagen, Long-chain collagen
Gene ID 1294
NCBI Accession NP_000085
UniProt Q02388
Research Area Extracellular Matrix
Pathways
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.1 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Collagen, Type VII (COL7) (Internal Region) antibody (ABIN374776) anti-Collagen, Type VII (COL7) (Internal Region) antibody
Background publications Ortiz-Urda, Garcia, Green et al.: "Type VII collagen is required for Ras-driven human epidermal tumorigenesis." in: Science (New York, N.Y.), Vol. 307, Issue 5716, pp. 1773-6, 2005 (PubMed).