GOT1 antibody (Internal Region)

Catalog No. ABIN374888

Product Details anti-GOT1 Antibody

Target: GOT1 (Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase 1) (GOT1))

Binding Specificity: AA 22-35, Internal Region

Reactivity: Human, Mouse

Host: Goat

Clonality: Polyclonal

Conjugate: This GOT1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to GOT1.

Cross-Reactivity (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-TADFREDPDPRKVN, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/16000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GOT1

Target: GOT1 (Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase 1) (GOT1))

Alternative Name: GOT1 (GOT1 Products)

Synonyms: ASTQTL1 antibody, GIG18 antibody, cAspAT antibody, cCAT antibody, AST antibody, ISSD antibody, NSD antibody, SD antibody, SIALIN antibody, SIASD antibody, SLD antibody, xr406 antibody, CASPAT antibody, ASPARTATE AMINOTRANSFERASE antibody, ATAAT antibody, MATERNAL EFFECT EMBRYO ARREST 17 antibody, MEE17 antibody, T26C19.9 antibody, T26C19_9 antibody, aspartate aminotransferase antibody, aatA antibody, 83.t00021 antibody, AI789014 antibody, Got-1 antibody, Aspat antibody, Gaspat antibody, AL022787 antibody, FABP-pm antibody, Got-2 antibody, mAspAT antibody, ASPATA antibody, glutamic-oxaloacetic transaminase 1 antibody, solute carrier family 17 member 5 antibody, glutamic-oxaloacetic transaminase 1 homeolog antibody, aspartate aminotransferase antibody, glutamic-oxaloacetic transaminase 1, soluble antibody, glutamic-oxaloacetic transaminase 2 antibody, glutamatic-oxaloacetic transaminase 2, mitochondrial antibody, GOT1 antibody, SLC17A5 antibody, got1.S antibody, AAT antibody, aspC antibody, EHI_006080 antibody, AST2 antibody, ast2 antibody, got1 antibody, Got1 antibody, GOT2 antibody, Got2 antibody

Background: Aspartate Aminotransferase [Glutamate oxaloacetate transaminase] is a ubiquitous pyridoxal phosphate-dependent enzyme which exists in both mitochondrial and cytosolic forms. The enzyme plays an important role in amino acid metabolism and in the urea and tricarboxylic acid cycles. The 2 isoenzymes are homodimeric. In liver about 80 % of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic. Although the mitochondrial and soluble forms of GOT are coded by different chromosomes, the 2 show close homology in amino acid sequence and were presumably derived from a common ancestral gene. Serum GOT [with SGPT] levels are usually elevated in states of hepatocellular injury (injury to the liver cells), the highest levels are associated with hepatitis of a viral origin. High levels are also found after myocardial infarction, when SGPT levels are lower.Synonyms: Aspartate aminotransferase, Glutamate oxaloacetate transaminase 1, Transaminase A

Gene ID: 2805, 9606

UniProt: P17174

Pathways: Hepatitis C, Monocarboxylic Acid Catabolic Process, Methionine Biosynthetic Process