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Cytohesin 2 antibody (N-Term)

CYTH2 Reactivity: Human, Rat, Mouse, Dog WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN374897
  • Target See all Cytohesin 2 (CYTH2) Antibodies
    Cytohesin 2 (CYTH2)
    Binding Specificity
    • 15
    • 9
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 32
    • 19
    • 19
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog
    Host
    • 40
    • 3
    • 1
    Goat
    Clonality
    • 42
    • 2
    Polyclonal
    Conjugate
    • 20
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Cytohesin 2 antibody is un-conjugated
    Application
    • 43
    • 20
    • 13
    • 13
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Specificity
    This antibody reacts to ARNO / cytohesin 2.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Canine.
    Species reactivity (tested):Human, Rat.
    Purification
    Affinity chromatography
    Immunogen
    Peptide with sequence EDGVYEPPDLTP-C, from the N Terminus of the protein sequence
    Top Product
    Discover our top product CYTH2 Primary Antibody
  • Application Notes
    Peptide ELISA: 1/32000. Western Blot: 0.5 - 1.5 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    0,5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Cytohesin 2 (CYTH2)
    Alternative Name
    Cytohesin 2 (CYTH2 Products)
    Synonyms
    ARNO antibody, CTS18 antibody, CTS18.1 antibody, PSCD2 antibody, PSCD2L antibody, SEC7L antibody, Sec7p-L antibody, Sec7p-like antibody, CLM2 antibody, Pscd2 antibody, Arno antibody, Sec7 antibody, Sec7B antibody, pscd2 antibody, MGC84366 antibody, CYTH2 antibody, cyth2 antibody, cytohesin 2 antibody, cytohesin-2 antibody, cytohesin 2 L homeolog antibody, si:dkey-283b15.4 antibody, CYTH2 antibody, PTRG_08834 antibody, Cyth2 antibody, cyth2.L antibody, cyth2 antibody, si:dkey-283b15.4 antibody
    Background
    The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf's activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).Synonyms: ARF exchange factor, ARF nucleotide-binding site opener, ARNO, CYTH2, PH, PSCD2, PSCD2L, SEC7 and coiled-coil domain-containing protein 2
    Gene ID
    9266, 9606
    UniProt
    Q99418
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