MC2R
Reactivity: Human
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0,5 mg/mL
Buffer
Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
MC2 receptor is the second member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. MC2 receptor is the smallest MCR and the smallest known GPCR (297 amino acids). It exclusively binds the adrenocorticotrophic hormone (ACTH) and this binding plays a pivotal role in homeostasis, metabolism, and stress response. In contrast, the other four MCRs are activated by both ACTH and melanocyte-stimulating hormones (MSHs and mainly alpha-MSH). The MC2 receptor is predominantly expressed in the adrenal gland but is also found in the murine adipocyte. Mutations in MC2R can result in familial glucocorticoid deficiency.Synonyms: ACTH receptor, ACTH-R, ACTHR, Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, MC2R