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PC antibody (Internal Region)

PC Reactivity: Human, Mouse, Rat, Pig, Cow, Dog WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN374944
  • Target See all PC Antibodies
    PC (Pyruvate Carboxylase (PC))
    Binding Specificity
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 16
    • 15
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Pig, Cow, Dog
    Host
    • 23
    • 1
    • 1
    Goat
    Clonality
    • 24
    • 1
    Polyclonal
    Conjugate
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    This PC antibody is un-conjugated
    Application
    • 24
    • 17
    • 14
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    C-KFKEVKKAYV EANQ
    Specificity
    Recognizes Pyruvate Carboxylase (PC).
    Cross-Reactivity (Details)
    Species reactivity (expected):Human, Rat, Canine, Bovine, Porcine.
    Species reactivity (tested):Mouse.
    Purification
    Affinity Chromatography
    Immunogen
    Peptide with sequence from the internal region of the protein sequence according to NP_000911.2, NP_001035806.1 and NP_071504.2.
    Top Product
    Discover our top product PC Primary Antibody
  • Application Notes
    Peptide ELISA: 1/16000. Western Blot: 0.03 - 0.1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    PC (Pyruvate Carboxylase (PC))
    Alternative Name
    Pyruvic Carboxylase (PC) (PC Products)
    Synonyms
    BcDNA antibody, BcDNA:GH06348 antibody, Dmel\\CG1516 antibody, PC antibody, pyc antibody, wu:fb82g08 antibody, wu:fj85g01 antibody, PCX antibody, BA4157 antibody, Pc antibody, Pcb antibody, PCB antibody, Pcx antibody, Pyruvate carboxylase antibody, pyruvate carboxylase b antibody, PYruvate Carboxylase antibody, pyruvate carboxylase antibody, pyruvate carboxylase Pyr1 antibody, PCB antibody, pcxb antibody, pyc-1 antibody, PC antibody, pyc antibody, pyr1 antibody, CNF00650 antibody, PYC1 antibody, Ndas_1152 antibody, Ilyop_2503 antibody, Calni_0495 antibody, Ftrac_1004 antibody, Plabr_3574 antibody, Sgly_2936 antibody, Celly_0558 antibody, Hipma_0131 antibody, Halhy_1567 antibody, Mesop_1269 antibody, Pcx antibody, Pc antibody
    Background
    Pyruvate Carboxylase (PC, PCB) requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. PCB is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.Synonyms: PCB, Pyruvate carboxylase mitochondrial
    Molecular Weight
    130kDa (NP_000911.2, NP_001035806.1 and NP_071504.2).
    Gene ID
    5091, 9606
    UniProt
    P11498
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