KPNA6 antibody (Internal Region)

Catalog No. ABIN374979

Product Details anti-KPNA6 Antibody

Target: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This KPNA6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects KPNA6.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Dog, Pig, Bovine.
Species reactivity (tested):Human.

Purification: Affinity Chromatography.

Immunogen: Peptide with sequence C-STTGESVITREMVE, from the internal of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/128000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KPNA6

Target: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Alternative Name: KPNA6 / Importin alpha-7 (KPNA6 Products)

Synonyms: IPOA7 antibody, Kpna5 antibody, NPI-2 antibody, KPNA7 antibody, karyopherin subunit alpha 6 antibody, karyopherin (importin) alpha 6 antibody, karyopherin alpha 6 (importin alpha 7) antibody, karyopherin alpha 6 (importin alpha 7) S homeolog antibody, KPNA6 antibody, Kpna6 antibody, kpna6.S antibody

Background: Nucleocytoplasmic transport, a signal and energy dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.Synonyms: IPOA7, KPNA6, Karyopherin subunit alpha-6

Gene ID: 23633

NCBI Accession: NP_036448

UniProt: O60684

Pathways: Protein targeting to Nucleus