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IRAK3 antibody (Interleukin-1 Receptor-Associated Kinase 3) (C-Term)

Details for Product anti-IRAK3 Antibody No. ABIN375025, Supplier: Log in to see
Antigen
  • IRAK3
  • si:dkey-150i15.2
  • ASRT5
  • IRAKM
  • IrakM
  • 4833428C18Rik
  • AI563835
  • IRAK-M
Alternatives
anti-Mouse (Murine) IRAK3 antibody for Western Blotting
Epitope
C-Term, Internal Region
56
18
15
8
6
5
5
5
5
4
3
2
2
2
2
2
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
105
49
30
1
Host
Goat
115
15
13
Clonality
Polyclonal
Conjugate
This IRAK3 antibody is un-conjugated
6
6
5
5
5
5
Application
Western Blotting (WB)
132
80
34
18
13
8
4
2
1
1
1
1
1
1
1
Supplier
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Immunogen Peptide with sequence C-GHSYGSKPMEKR, from the internal region (near the CTerminus) of the protein sequence
Specificity This antibody recognizes IRAK3 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Mouse, Rat.
Purification Affinity chromatography
Alternative Name IRAK3 (IRAK3 Antibody Abstract)
Background Reduced expression of IRAK-1 and increased expression of IRAK-M after CpG DNA pretreatment resulted in the hyporesponsiveness of macrophages that leads to the protection of mice from hepatic injury and death caused by CpG DNA/D-GalN. Endotoxin tolerance was significantly reduced in macrophages from IRAK-M knockout mice. IRAK-M regulates TLR signaling and innate immune homeostasis. induction of IRAK-M and inhibition of kinase activity of IRAK-1 are crucial to PGN-induced tolerance in macrophages. IRAK-M is a key regulator of the bone loss that is due to osteoclastic resorption of bone. IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages in the presence of Mycobacterium tuberculosis lipoarabinomannan. These findings indicate that IRAK-M selectively attenuates p38 activation and inhibits innate immunity through stabilizing MKP-1. IRAK-M is directly involved in the regulation of both innate and adaptive immune signaling processes, and deletion of IRAK-M enhances host anti-tumor immune response.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
Gene ID 11213
NCBI Accession NP_001135995
UniProt Q9Y616
Pathways TLR Signaling
Application Notes Peptide ELISA: 1/64000. Western Blot: 0.05 - 0.2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-IRAK3 antibody (Interleukin-1 Receptor-Associated Kinase 3) (C-Term) (ABIN375025) anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term), (Internal Region) antibody
Background publications Balaci, Spada, Olla et al.: "IRAK-M is involved in the pathogenesis of early-onset persistent asthma. ..." in: American journal of human genetics, Vol. 80, Issue 6, pp. 1103-14, 2007 (PubMed).