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Fat Mass and Obesity-Associated (FTO) (Internal Region) antibody

Details for Product No. ABIN375028, Supplier: Log in to see
Antigen
  • AW743446
  • mKIAA1752
  • RGD1305121
Epitope
Internal Region
38
12
6
4
4
2
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
105
56
36
10
6
6
6
4
4
3
1
1
Host
Goat
80
24
14
5
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
103
68
35
14
12
11
8
6
3
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Immunogen Peptide with sequence QQKPDCRPYWEKDD, from the Internal region of the protein sequence
Specificity This antibody reacts to FTO.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine, Porcine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name FTO (FTO Antibody Abstract)
Background Variants in the FTO (fat mass and obesity associated) gene, encoding for protein, fatso, are associated with increased body mass index and obesity in humans. The precise function of this protein remains to be determined. There are four isoforms produced by alternative splicing (FASTA: FTO isoform 1, 2, 3, and 4).Synonyms: Fat mass and obesity-associated protein, KIAA1752
Gene ID 26383
NCBI Accession NP_036066
UniProt Q8BGW1
Research Area Cardiovascular, Atherosclerosis, Metabolism
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Fat Mass and Obesity-Associated (FTO) (Internal Region) antibody (ABIN375028) anti-Fat Mass and Obesity-Associated (FTO) (Internal Region) antibody
Background publications Gerken, Girard, Tung et al.: "The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. ..." in: Science (New York, N.Y.), Vol. 318, Issue 5855, pp. 1469-72, 2007 (PubMed).