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BAG5 antibody (BCL2-Associated Athanogene 5) (Internal Region)

Details for Product anti-BAG5 Antibody No. ABIN375061, Supplier: Log in to see
Antigen
  • 1600025G07Rik
  • 4930405J06Rik
  • BAG-5
  • bag-5
  • BAG5
  • zgc:114117
Epitope
Internal Region
38
23
16
11
7
6
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
139
32
31
5
5
3
Host
Goat
88
44
10
Clonality
Polyclonal
Conjugate
This BAG5 antibody is un-conjugated
9
9
9
5
5
5
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
106
70
15
11
9
8
5
2
2
1
1
Supplier
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Immunogen Peptide with sequence DPQGEEKCKAARKQ, from the internal region of the protein sequence
Specificity This antibody reacts to BAG5. This antibody is expected to recognise reported isoform a and isoform b.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name BAG5 (BAG5 Antibody Abstract)
Background BAG5 is a member of the BAG1 related protein family. BAG1 is an anti apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL 2, Raf protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. A BAG domain near the C terminus, may bind and inhibit the chaperone activity of Hsc70/Hsp70. It has been hypothesized that the BAG5 protein will induce the death of nigral neurons through its predicted interaction with hsp70, which will cause increased protein aggregation and cell death by disinhibition of hsp70's anti apoptotic function. It is believed that BAG5 will play an important role in the mechanisms of neuronal death. BAG5 may also be of interest due to its possible role as a modulator of the hsp70/hsp40 chaperone axis or its possible interaction and coordination of localization/modulation of other BAG containing proteins via BAG-BAG heterodimerization.Synonyms: BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5, KIAA0873
Gene ID 9529, 9606
UniProt Q9UL15
Application Notes Peptide ELISA: 1/16000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-BAG5 antibody (BCL2-Associated Athanogene 5) (Internal Region) (ABIN375061) anti-BCL2-Associated Athanogene 5 (BAG5) (Internal Region) antibody
Background publications Kalia, Lee, Smith, Liu, Crocker, Thorarinsdottir, Glover, Fon, Park, Lozano: "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration." in: Neuron, Vol. 44, Issue 6, pp. 931-45, 2004