ESRRG antibody (Internal Region)

Catalog No. ABIN375117

Product Details anti-ESRRG Antibody

Target: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This ESRRG antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to ESRRG. This antibody is expected to recognise isoform 1.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence CRMSNKDRHIDS, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/16000. Western Blot: 0.2 - 0.6 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ESRRG

Target: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Alternative Name: Estrogen-Related Receptor gamma (ESRRG Products)

Synonyms: ERR3 antibody, ERRgamma antibody, NR3B3 antibody, ESRRG antibody, USH2A antibody, DKFZp459J0417 antibody, err3 antibody, nr3b3 antibody, LOC100219115 antibody, errg antibody, errgamma antibody, esrrg antibody, errb/g antibody, esrrgl antibody, errbeta/gamma antibody, Errg antibody, mKIAA0832 antibody, estrogen related receptor gamma antibody, estrogen-related receptor gamma antibody, estrogen-related receptor gamma a antibody, estrogen-related receptor gamma b antibody, ESRRG antibody, esrrg antibody, Esrrg antibody, esrrga antibody, esrrgb antibody

Background: Estrogen related receptor (ERR gamma), a NR3 Steroid Receptor is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members (1,2, and 3) share an almost identical DNA binding domain, which has 68 % amino acid identity with that of estrogen receptor. Studies involving the crystal structure of the LBD have shown a complex between ERR3 and SRC1. ERR gamma has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre mRNA undergoes extensive alternative splicing at the 5 prime end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development.Synonyms: ERR gamma-2, ERR3, ERRG2, ESRRG, Estrogen receptor-related protein 3, KIAA0832, NR3B3, Nuclear receptor subfamily 3 group B member 3

Gene ID: 2104, 9606

UniProt: P62508

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway