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APOC1 antibody (C-Term)

APOC1 Reactivity: Human IHC (p) Host: Goat Polyclonal unconjugated
Catalog No. ABIN375143
  • Target See all APOC1 Antibodies
    APOC1 (Apolipoprotein C-I (APOC1))
    Binding Specificity
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    C-Term
    Reactivity
    • 41
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 34
    • 7
    • 5
    • 1
    Goat
    Clonality
    • 43
    • 4
    Polyclonal
    Conjugate
    • 26
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APOC1 antibody is un-conjugated
    Application
    • 26
    • 18
    • 18
    • 11
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody recognizes Apolipoprotein CI (Apo CI).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
    Immunogen
    Peptide with sequence C-ETFQKVKEKLKIDS, from the C-Terminus of the protein sequence according to NP_001636.1.
    Top Product
    Discover our top product APOC1 Primary Antibody
  • Application Notes
    Peptide ELISA: Detection Limit Dilution: 1/8000. Immunohistochemistry on Paraffin Sections: 3-5 μg/mL. In paraffin embedded Human Liver shows spotty staining in the cytoplasm of hepatocytes.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    APOC1 (Apolipoprotein C-I (APOC1))
    Alternative Name
    Apolipoprotein C I (Apo CI) (APOC1 Products)
    Synonyms
    Apo-CIB antibody, ApoC-IB antibody, ALPCI antibody, LRRG04 antibody, APOC1 antibody, apoc1 antibody, apolipoprotein C1 antibody, apolipoprotein C-I antibody, Apolipoprotein C-I antibody, APOC1 antibody, Apoc1 antibody, apoc1 antibody
    Background
    Apolipoprotein CI is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).Synonyms: Apo-CI, Ap °C-I, Ap °C1, Apolipoprotein C-I, Apolipoprotein C1
    Gene ID
    341, 9606
    UniProt
    P02654
    Pathways
    Apoptosis
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