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NR1H4 antibody (Internal Region)

NR1H4 Reactivity: Human, Dog WB, EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN375197
  • Target See all NR1H4 Antibodies
    NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
    Binding Specificity
    • 16
    • 12
    • 9
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 56
    • 28
    • 27
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    Human, Dog
    Host
    • 53
    • 5
    • 1
    Goat
    Clonality
    • 54
    • 5
    Polyclonal
    Conjugate
    • 29
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NR1H4 antibody is un-conjugated
    Application
    • 51
    • 27
    • 13
    • 13
    • 12
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Sequence
    KSCREKTELT PDQQ
    Specificity
    This antibody recognizes HRR1.
    Cross-Reactivity (Details)
    Species reactivity (expected):Canine.
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide with sequence from the internal region of the protein sequence Genename: NR1H4
    Top Product
    Discover our top product NR1H4 Primary Antibody
  • Application Notes
    ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
    Alternative Name
    NR1H4 / FXR (NR1H4 Products)
    Synonyms
    zgc:110190 antibody, zgc:92742 antibody, NR1H4 antibody, BAR antibody, FXR antibody, HRR-1 antibody, HRR1 antibody, RIP14 antibody, AI957360 antibody, Fxr antibody, Rxrip14 antibody, nuclear receptor subfamily 1, group H, member 5 S homeolog antibody, nuclear receptor subfamily 1, group H, member 4 antibody, nuclear receptor subfamily 1 group H member 4 antibody, nr1h5.S antibody, nr1h4 antibody, NR1H4 antibody, Nr1h4 antibody
    Background
    Bile Acid Receptor NR1H4 is a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. It represses the transcription of the cholesterol 7 alpha hydroxylase gene and activates the intestinal bile acid binding protein. The NR1H4 gene encodes a protein that has a central role in lipid homeostasis and also regulates carbohydrate metabolism.Synonyms: BAR, Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, HRR1, Nuclear receptor subfamily 1 group H member 4, RIP14, Retinoid X receptor-interacting protein 14
    Gene ID
    9971
    NCBI Accession
    NP_001193906
    UniProt
    Q96RI1
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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