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NR4A1 antibody (Internal Region, Isoform A)

NR4A1 Reactivity: Human, Mouse, Rat, Dog WB, EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN375222
  • Target See all NR4A1 Antibodies
    NR4A1 (Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1))
    Binding Specificity
    • 22
    • 16
    • 8
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region, Isoform A
    Reactivity
    • 84
    • 42
    • 39
    • 9
    • 9
    • 9
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog
    Host
    • 84
    • 2
    • 2
    Goat
    Clonality
    • 82
    • 6
    Polyclonal
    Conjugate
    • 54
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This NR4A1 antibody is un-conjugated
    Application
    • 67
    • 31
    • 19
    • 15
    • 15
    • 14
    • 14
    • 8
    • 7
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Sequence
    C-GRLPSKPKQP PDAS
    Specificity
    This antibody is expected to recognise isoform a only.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat, Canine (Dog).
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity Chromatography.
    Immunogen
    Synthetic peptide from an internal region of Human NR4A1
    Top Product
    Discover our top product NR4A1 Primary Antibody
  • Application Notes
    Peptide ELISA: 1/32000. Western Blot: 1-3 μg/mL. Detects a band of approximately 64 kDa (predicted molecular weight: 64 kDa). Immunohistochemistry on Paraffin Sections: 5 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    NR4A1 (Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1))
    Alternative Name
    NAK1 (NR4A1 Products)
    Synonyms
    GFRP1 antibody, HMR antibody, N10 antibody, NAK-1 antibody, NGFIB antibody, NP10 antibody, NUR77 antibody, TR3 antibody, NGFI-B antibody, Gfrp antibody, Hbr-1 antibody, Hbr1 antibody, Hmr antibody, TIS1 antibody, nur77 antibody, Ngfi-b antibody, Nur77 antibody, nuclear receptor subfamily 4 group A member 1 antibody, nuclear receptor subfamily 4, group A, member 1 antibody, NR4A1 antibody, Nr4a1 antibody
    Background
    Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases.Synonyms: Early Response Protein NAK1, GFRP1, HMR, N10, NR4A1, NUR77, Orphan Nuclear Receptor HMR, ST-59, TR3 Orphan Receptor
    Gene ID
    3164
    NCBI Accession
    NP_002126
    UniProt
    P22736
    Pathways
    Fc-epsilon Receptor Signaling Pathway, Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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