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VEGF3 (C-Term), (N-Term) antibody

Details for Product No. ABIN387759, Supplier: Log in to see
Antigen
Epitope
C-Term, N-Term
12
7
2
1
1
Reactivity
Human, Mouse (Murine)
21
3
Host
Mouse
11
10
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
19
13
9
9
1
Options
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Immunogen This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides selected from the N-terminal, central, and C-terminal regions of human VEGF3.
Clone 30AT1174-77
Isotype IgG1
Specificity This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides selected from the N-terminal, central, and C-terminal regions of human VEGF3.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Background The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
Synonyms: Vascular Endothelial Growth Factor C, VEGF-C, Vascular endothelial growth factor-related protein, VRP, Flt4 ligand, Flt4-L, VEGF3
Molecular Weight 46883 DA
Gene ID 7424
UniProt P49767
Research Area Cell Signaling, Cell Structure, Cancer, Cell Cycle
Application Notes WB = 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-VEGF3 (C-Term), (N-Term) antibody (ABIN387759) Western analysis of extracts from HDMEC cells using VEGF3 antibody.
Background publications Romero, Friel, Velez Edwards, Kusanovic, Hassan, Mazaki-Tovi, Vaisbuch, Kim, Erez, Chaiworapongsa, Pearce, Bartlett, Salisbury, Anant, Vovis, Lee, Gomez, Behnke, Oyarzun, Tromp, Williams, Menon: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Deguchi, Ichikawa, Soga, Watanabe, Kosuga, Takeshita, Konishi, Morimura, Tsujiura, Komatsu, Shiozaki, Okamoto, Fujiwara, Otsuji: "Clinical significance of vascular endothelial growth factors C and D and chemokine receptor CCR7 in gastric cancer." in: Anticancer research, Vol. 30, Issue 6, pp. 2361-6, 2010 (PubMed).

Johnatty, Beesley, Chen, Macgregor, Duffy, Spurdle, deFazio, Gava, Webb, Rossing, Doherty, Goodman, Lurie, Thompson, Wilkens, Ness, Moysich, Chang-Claude, Wang-Gohrke, Cramer, Terry, Hankinson, Tworoger, Garcia-Closas, Yang, Lissowska, Chanock, Pharoah, S: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Romero, Velez Edwards, Kusanovic, Hassan, Mazaki-Tovi, Vaisbuch, Kim, Chaiworapongsa, Pearce, Friel, Bartlett, Anant, Salisbury, Vovis, Lee, Gomez, Behnke, Oyarzun, Tromp, Williams, Menon: "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes." in: American journal of obstetrics and gynecology, Vol. 202, Issue 5, pp. 431.e1-34, 2010 (PubMed).