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Epithelial Cell Adhesion Molecule (EPCAM) antibody
Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA
|5 references available|
|Quantity||0.1 mg (0.75 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This EpCAM monoclonal antibody is generated from mice immunized with a purified recombinant EpCAM protein.|
|Description||Other names: CD326, CO-17A, CO17-1A, EGP, EGP-2, EGP34, EGP40, ESA, Ep-CAM, GA733-2, KS1/4, KSA, M4S1, MIC18, MK-1, TACST-1, TACSTD1, TROP1, hEGP-2|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||This EpCAM monoclonal antibody is generated from mice immunized with a purified recombinant EpCAM protein.|
|Molecular Weight||40 kDA|
Background: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
|Synonyms||EGP, ESA, KSA, M4S1, MK-1, EGP-2, EGP34, EGP40, KS1/4, MIC18, TROP1, CO-17A, Ep-CAM, hEGP-2, CO17-1A, GA733-2, TACST-1, TACSTD1, sb:cb6, tacstd, zgc:77119, wu:fj17g02, EPCAM, tacstd1, MGC80540, MGC127627, egp, ksa, m4s1, mk-1, cd326, egp40, mic18, trop1, ep-cam, hegp-2, co17-1a, ga733-2|
|Application Notes||ELISA~~1:1,000-2,500 Flow cytometry~~1:1,000-1:7,500 Immunoprecipitation 5 ?g per test|
|Buffer||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Stem Cells, Cell Structure, Cancer|
|Restrictions||For Research Use only|
|Immuniprecipitation cell lysates from MCF7 cells using 5 anti-Epithelial Cell Adhesion Molecule (EPCAM) antibody (Image 2)|
Lu, Lu, Liao et al.: "Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 8719-32, 2010 (PubMed).
Raffel, Eisenberger, Cupisti et al.: "Increased EpCAM expression in malignant insulinoma: potential clinical implications." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 162, Issue 2, pp. 391-8, 2010 (PubMed).
Lugli, Iezzi, Hostettler et al.: "Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer." in: British journal of cancer, Vol. 103, Issue 3, pp. 382-90, 2010 (PubMed).
Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).
Jiang, Zhang, Li et al.: "A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population." in: Breast cancer research and treatment, Vol. 126, Issue 2, pp. 487-95, 2011 (PubMed).