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Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (AA 367-384) antibody

Details for Product No. ABIN387774, Supplier: Login to see
Antigen
  • A3G
  • ARCD
  • ARP-9
  • ARP9
  • CEM-15
  • CEM15
  • bK150C2.7
  • dJ494G10.1
Epitope
AA 367-384
54
36
15
14
13
10
8
8
4
3
3
2
2
2
2
1
1
1
1
Reactivity
Human
169
5
4
Host
Mouse
130
20
19
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
11
11
11
10
10
10
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
140
99
64
20
11
7
5
1
Supplier
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Immunogen This monoclonal antibody is generated from mice immunized with a KLH conjugated synthetic peptide corresponding to aa 367-384 of CEM15.
Clone 34AT1147
Isotype IgG1
Specificity This monoclonal antibody is generated from mice immunized with a KLH conjugated synthetic peptide corresponding to aa 367-384 of CEM15.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CEM15 (APOBEC3G Antibody Abstract)
Background This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Synonyms: DNA dC->dU-editing enzyme APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, APOBEC-related protein, ARP-9, CEM15, CEM-15, APOBEC3G, MDS019
Molecular Weight 46408 DA
Gene ID 60489
Research Area Cell Cycle, Signaling, Chromatin, Cell Structure
Pathways
Application Notes Western blotting=1:100-500
Comment

Background: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.

Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (AA 367-384) antibody (ABIN387774) Western analysis of cell lysates from PBMC cells using CEM15 abtibody.
Product cited in: Zhao, Wang, Lou et al.: "APOBEC3G directly binds Hepatitis B virus core protein in cell and cell free systems." in: Virus research, Vol. 151, Issue 2, pp. 213-9, 2010 (PubMed).

Background publications Zhou, Wang, Liu et al.: "A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages." in: Immunology, Vol. 131, Issue 1, pp. 40-9, 2010 (PubMed).

Dang, Wang, York et al.: "Identification of a critical T(Q/D/E)x5ADx2(I/L) motif from primate lentivirus Vif proteins that regulate APOBEC3G and APOBEC3F neutralizing activity." in: Journal of virology, Vol. 84, Issue 17, pp. 8561-70, 2010 (PubMed).

Vartanian, Henry, Marchio et al.: "Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis." in: PLoS pathogens, Vol. 6, Issue 5, pp. e1000928, 2010 (PubMed).

Sadler, Stenglein, Harris et al.: "APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis." in: Journal of virology, Vol. 84, Issue 14, pp. 7396-404, 2010 (PubMed).

Fan, Ma, Nosaka et al.: "APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo." in: Journal of virology, Vol. 84, Issue 14, pp. 7278-87, 2010 (PubMed).