Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN387774

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms A3G, ARCD, ARP-9, ARP9, CEM-15, CEM15, bK150C2.7, dJ494G10.1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 5 references available
Catalog no. ABIN387774
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen This monoclonal antibody is generated from mice immunized with a KLH conjugated synthetic peptide corresponding to aa 367-384 of CEM15.
Clone 34AT1147
Isotype IgG1
Specificity This monoclonal antibody is generated from mice immunized with a KLH conjugated synthetic peptide corresponding to aa 367-384 of CEM15.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CEM15
Background This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Synonyms: DNA dC->dU-editing enzyme APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, APOBEC-related protein, ARP-9, CEM15, CEM-15, APOBEC3G, MDS019
Molecular Weight 46408 DA
Gene ID 60489
Research Area Cell Cycle, Signaling, Chromatin, Cell Structure
Application Notes ELISA~~1:1,000 Western blotting~~1:100~500
Comment

Background: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.

Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Fan, Ma, Nosaka et al.: "APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo." in: Journal of virology, Vol. 84, Issue 14, pp. 7278-87, 2010 (PubMed).

Sadler, Stenglein, Harris et al.: "APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis." in: Journal of virology, Vol. 84, Issue 14, pp. 7396-404, 2010 (PubMed).

Vartanian, Henry, Marchio et al.: "Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis." in: PLoS pathogens, Vol. 6, Issue 5, pp. e1000928, 2010 (PubMed).

Dang, Wang, York et al.: "Identification of a critical T(Q/D/E)x5ADx2(I/L) motif from primate lentivirus Vif proteins that regulate APOBEC3G and APOBEC3F neutralizing activity." in: Journal of virology, Vol. 84, Issue 17, pp. 8561-70, 2010 (PubMed).

Zhou, Wang, Liu et al.: "A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages." in: Immunology, Vol. 131, Issue 1, pp. 40-9, 2010 (PubMed).

Alternatives for antigen "Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G)", type "Antibodies"
Hosts (51), (9), (8)
Reactivities (64), (3), (1)
Applications (63), (29), (22), (20), (2), (1)
Epitopes (22), (12), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Beacon