Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibody

Details for Product No. ABIN387778
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Antigen
Synonyms H3-K9-HMTase 1, KMT1A, MG44, SUV39H, mIS6, AI852103, AL022883, DXHXS7466e, RGD1565028, fe02c04, suv39h1, wu:fe02c04, zgc:101027, kmt1a, suv39h
Epitope
N-Term
(28), (7), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(58), (22), (16), (14), (14), (12), (1), (1)
Host
Mouse
(45), (14)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(48), (31), (10), (10), (7), (5), (2), (1)
Pubmed 5 references available
Catalog no. ABIN387778
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen This SUV39H1 antibody was raised using purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.
Clone 42AT239-96-72
Isotype IgG1
Specificity This SUV39H1 antibody was raised using purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name SUV39H1
Background This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
Synonyms: Histone-lysine N-methyltransferase, H3 lysine-9 specific 1, Suppressor of variegation 3-9 homolog 1, KMT1A
Molecular Weight 47907 DA
Gene ID 6839
UniProt NP_003164
Research Area Signaling, Protein Modifications, Cancer, Chromatin, Cell Structure
Application Notes WB = 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibody Western analysis of extracts from 293 cells using SUV39H1 antibody.
Background publications Spensberger, Delwel: "A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a." in: FEBS letters, Vol. 582, Issue 18, pp. 2761-7, 2008 (PubMed).

Li, Chen, Kabra et al.: "Inhibition of SUV39H1 methyltransferase activity by DBC1." in: The Journal of biological chemistry, Vol. 284, Issue 16, pp. 10361-6, 2009 (PubMed).

Cherrier, Suzanne, Redel et al.: "p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1." in: Oncogene, Vol. 28, Issue 38, pp. 3380-9, 2009 (PubMed).

Goyama, Nitta, Yoshino et al.: "EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization." in: Leukemia, Vol. 24, Issue 1, pp. 81-8, 2010 (PubMed).

Chen, Li, Zwolinska et al.: "MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output." in: The EMBO journal, Vol. 29, Issue 15, pp. 2538-52, 2010 (PubMed).

Hosts (45), (14)
Reactivities (58), (22), (16), (14), (14), (12), (1), (1)
Applications (48), (31), (10), (10), (7), (5), (2), (1)
Conjugates (4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (28), (7), (2), (2), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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