|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) antibody
|Synonyms||MG44, KMT1A, SUV39H|
Alternatives Western Blotting (WB), ELISA
|5 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This SUV39H1 antibody was raised using purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.|
|Description||Other names: Histone-lysine N-methyltransferase, H3 lysine-9 specific 1, Suppressor of variegation 3-9 homolog 1,, KMT1A|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||This SUV39H1 antibody was raised using purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.|
|Molecular Weight||47907 DA|
Background: This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
|Application Notes||ELISA~~1:1,000 Western blotting~~1:100~500|
|Buffer||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Signaling, Protein Modifications, Cancer, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
|Western analysis of extracts from 293 cells using SUV39H1 antibody.|
Spensberger, Delwel: "A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a." in: FEBS letters, Vol. 582, Issue 18, pp. 2761-7, 2008 (PubMed).
Li, Chen, Kabra et al.: "Inhibition of SUV39H1 methyltransferase activity by DBC1." in: The Journal of biological chemistry, Vol. 284, Issue 16, pp. 10361-6, 2009 (PubMed).
Cherrier, Suzanne, Redel et al.: "p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1." in: Oncogene, Vol. 28, Issue 38, pp. 3380-9, 2009 (PubMed).
Goyama, Nitta, Yoshino et al.: "EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 24, Issue 1, pp. 81-8, 2010 (PubMed).
Chen, Li, Zwolinska et al.: "MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output." in: The EMBO journal, Vol. 29, Issue 15, pp. 2538-52, 2010 (PubMed).
|Hosts||Rabbit (19), Mouse (4)|
|Reactivities||Human (21), Mouse (Murine) (9), Rat (Rattus) (6), Cow (Bovine) (2), Dog (Canine) (2), Xenopus laevis (1), Zebrafish (1)|
|Applications||Western Blotting (WB) (22), ELISA (12), Immunohistochemistry (IHC) (3), Immunoprecipitation (IP) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2)|
|Epitopes||N-Term (6), AA 1-412 (1), AA 368-392 (1), AA 82-415 (1), C-Term (1)|