Beclin 1, Autophagy Related (BECN1) antibody

Details for Product No. ABIN387797
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Antigen
Synonyms ATG6, VPS30, beclin1, 4921513J16Rik, 5430417M23Rik, Atg6, zgc:73097, beclin-1, atg6, vps30, Beclin-1, becn1
Reactivity
Human
(165), (81), (57), (32), (30), (21), (18), (15), (12), (6), (2), (1)
Host
Mouse
(123), (53), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC)
(162), (55), (50), (46), (37), (23), (18), (14), (10), (5), (5), (3), (1)
Pubmed 5 references available
Catalog no. ABIN387797
Quantity 0.1 mL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This Beclin 1 antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Clone 15CT26
Isotype IgG3
Specificity This Beclin 1 antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Purification Ascites
Alternative Name Beclin 1
Background Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).
Synonyms: BECN1, ATG6, VPS30, beclin1, ATG6 autophagy related 6 homolog, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein), beclin 1 (coiled-coil, moesin-like BCL2-interacting protein), beclin-1, coiled-coil myosin-like BCL2-interacting protein
Pathways: Regulation of autophagy
Molecular Weight 51765 Da
Gene ID 8678
UniProt Q14457
Research Area Cell Signaling, Cell Structure, Autophagy
Application Notes IF = 1:100, WB = 1:50-2000, IHC = 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Beclin 1, Autophagy Related (BECN1) antibody (LEFT)Western blot analysis of anti-BECN1 Mab (ABIN387797) in HepG2, 293, Jurkat and Hela cell line lysates (35 µg/lane). BECN1 (arrow) was detected using the Mab ascites (1:2000 dilution). (RIGHT)Western blot analysis of anti-BECN1 Mab (CA080116A) in recombinant BECN1 protein. BECN1(arrow) was detected using the ascites Mab (1:2000 dilution). Breast CA section stained with Autophagy Beclin 1 Antibody Cat. # ABIN387797 at a 1:50 dilution. Data courtesy of Dr. Anita Thyagarajan, Cancer Research Laboratory, Methodist Research Institute, Indianapolis, Indiana.
anti-Beclin 1, Autophagy Related (BECN1) antibody (2) anti-Beclin 1, Autophagy Related (BECN1) antibody (Image 2)
Background publications Sun, Liu, Jin et al.: "Over-expression of the Beclin1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells." in: Cancer letters, Vol. 294, Issue 2, pp. 204-10, 2010 (PubMed).

Li, Chen, Wu et al.: "Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors." in: BMC cancer, Vol. 10, pp. 98, 2010 (PubMed).

Jaeger, Pickford, Sun et al.: "Regulation of amyloid precursor protein processing by the Beclin 1 complex." in: PLoS ONE, Vol. 5, Issue 6, pp. e11102, 2010 (PubMed).

Niu, Cheng, Ren et al.: "Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis." in: FEBS letters, Vol. 584, Issue 16, pp. 3519-24, 2010 (PubMed).

Metzger, Saukko, Van Che et al.: "Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7." in: Human genetics, Vol. 128, Issue 4, pp. 453-9, 2010 (PubMed).

Hosts (123), (53), (1), (1)
Reactivities (165), (81), (57), (32), (30), (21), (18), (15), (12), (6), (2), (1)
Applications (162), (55), (50), (46), (37), (23), (18), (14), (10), (5), (5), (3), (1)
Conjugates (6), (6), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (17), (7), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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