|+1 404 474 4654|
|+1 888 205 9894 (TF)|
SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody
|Synonyms||ANOP3, MCOPS3, MGC2413, RGD1565646, SOX2, MGC148683, lcc, ysb, Sox-2|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA
|5 references available|
|Quantity||50 ul mg (Ascites) (Variants)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Human SOX2 recombinant protein is used to produce this monoclonal antibody.|
|Description||Other names: Transcription factor SOX-2|
|Characteristics||Mouse Monoclonal Antibody (Mab)|
|Specificity||Human SOX2 recombinant protein is used to produce this monoclonal antibody.|
|Molecular Weight||34310 DA|
Background: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
|Application Notes||The suggested dilution is: ELISA ~~ 1:10000 Western blotting~~ 1:200~2000 Immunohistochemistry ~~ 1:50~100 Flow cytometric~~1:50~100|
|Buffer||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Stem Cells, Transcription Factors, Signaling|
|Restrictions||For Research Use only|
Reis, Tyler, Schneider et al.: "Examination of SOX2 in variable ocular conditions identifies a recurrent deletion in microphthalmia and lack of mutations in other phenotypes." in: Molecular vision, Vol. 16, pp. 768-73, 2010 (PubMed).
Gonzalez-Rodriguez, Pelcastre, Tovilla-Canales et al.: "Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases." in: The British journal of ophthalmology, Vol. 94, Issue 8, pp. 1100-4, 2010 (PubMed).
Ge, Zhou, Chen et al.: "Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells." in: Biochemical and biophysical research communications, Vol. 397, Issue 4, pp. 711-7, 2010 (PubMed).
Sholl, Barletta, Yeap et al.: "Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma." in: The American journal of surgical pathology, Vol. 34, Issue 8, pp. 1193-8, 2010 (PubMed).
Zhang, Efendic, Brismar et al.: "Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus." in: BMC medical genetics, Vol. 11, pp. 116, 2010 (PubMed).