You are viewing an incomplete version of our website. Please click to reload the website as full version.

IKBKG antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma) (full length)

Details for Product anti-IKBKG Antibody No. ABIN387828, Supplier: Log in to see
Antigen
  • nemo
  • fj33c07
  • wu:fj33c07
  • zgc:113492
  • MGC97885
  • IKBKG
  • IKBKG_1
  • IKBKG_2
  • CG16910
  • DmIKK-gamma
  • DmIKKgamma
  • Dmel\\CG16910
  • Dmikkgamma
  • IKK
  • IKK-gamma
  • IKK[[gamma]]
  • IKKg
  • IKKgamma
  • KEY
  • Kenny
  • Key
  • dIKK
  • dIKK-gamma
  • dmIKKgamma
  • AMCBX1
  • FIP-3
  • FIP3
  • Fip3p
  • IP
  • IP1
  • IP2
  • IPD2
  • NEMO
  • ZC2HC9
  • Nemo
  • 1110037D23Rik
  • AI848108
  • AI851264
  • AW124339
  • IKK[g]
Alternatives
anti-Human IKBKG antibody for Western Blotting
Epitope
full length
32
29
28
17
13
12
10
8
6
5
5
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
255
73
60
5
4
4
2
2
2
2
2
1
1
Host
Mouse
216
43
2
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This IKBKG antibody is un-conjugated
8
7
7
5
4
4
4
4
4
4
4
4
3
3
3
Application
Western Blotting (WB)
190
102
60
46
35
32
15
4
3
3
3
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen This IKK gamma antibody was raised using purified His-tagged recombinant full length human IKK gamma.
Clone 55AT986-5-78
Isotype IgG1
Specificity This IKK gamma antibody was raised using purified His-tagged recombinant full length human IKK gamma.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name IKK gamma (IKBKG Antibody Abstract)
Background This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
Synonyms: NF-kappaB essential modulator, NEMO, NF-kappaB essential modifier, Inhibitor of nuclear factor kappa-B kinase gamma subunit, IkB kinase gamma subunit, I-kappa-B kinase gamma, IKKG, IkB kinase-associated protein 1, IKKAP1, FIP-3
Molecular Weight 48197 DA
Gene ID 8517
UniProt Q9Y6K9
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes WB = 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 0.275 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-IKBKG antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma) (full length) (ABIN387828) The anti-IKKgamma Mab (ABIN387828) is used in Western blot to detect IKKgamma in ZR75...
Product cited in: Panopoulos, Harraz, Engelhardt et al.: "Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB ..." in: The Journal of biological chemistry, Vol. 280, Issue 4, pp. 2912-23, 2005 (PubMed).

Background publications Mooster, Cancrini, Simonetti et al.: "Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 1, pp. 127-32.e7, 2010 (PubMed).

Hsiao, Lin, Chiang et al.: "NEMO gene mutations in Chinese patients with incontinentia pigmenti." in: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 109, Issue 3, pp. 192-200, 2010 (PubMed).

Fusco, DUrso, Miano et al.: "The LCR at the IKBKG locus is prone to recombine." in: American journal of human genetics, Vol. 86, Issue 4, pp. 650-2; author reply 652-3, 2010 (PubMed).

Ammirante, Rosati, Arra et al.: "IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 16, pp. 7497-502, 2010 (PubMed).

de Jong, Albrecht, Schmidt et al.: "Activation of noncanonical NF-kappaB signaling by the oncoprotein Tio." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 16495-503, 2010 (PubMed).