Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (full length) antibody

Details for Product No. ABIN387828
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Antigen
Synonyms
nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKBKG_2, CG16910, DmIKK-gamma, DmIKKgamma, Dmel\\CG16910, Dmikkgamma, IKK, IKK-gamma, IKK[[gamma]], IKKg, IKKgamma, KEY, Kenny, Key, dI ... show more
nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKBKG_2, CG16910, DmIKK-gamma, DmIKKgamma, Dmel\\CG16910, Dmikkgamma, IKK, IKK-gamma, IKK[[gamma]], IKKg, IKKgamma, KEY, Kenny, Key, dIKK, dIKK-gamma, dmIKKgamma, AMCBX1, FIP-3, FIP3, Fip3p, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, Nemo, 1110037D23Rik, AI848108, AI851264, AW124339, IKK[g] show less
Epitope
full length
(25), (24), (20), (15), (12), (10), (9), (8), (7), (7), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(216), (47), (45), (25), (14), (2), (2), (2), (1)
Host
Mouse
(183), (34), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (8), (8), (5), (5), (5), (5), (5), (5), (5), (5), (3), (3), (3)
Application
Western Blotting (WB)
(163), (94), (50), (43), (38), (25), (23), (23), (2), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN387828
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Immunogen This IKK gamma antibody was raised using purified His-tagged recombinant full length human IKK gamma.
Clone 55AT986-5-78
Isotype IgG1
Specificity This IKK gamma antibody was raised using purified His-tagged recombinant full length human IKK gamma.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name IKK gamma
Background This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
Synonyms: NF-kappaB essential modulator, NEMO, NF-kappaB essential modifier, Inhibitor of nuclear factor kappa-B kinase gamma subunit, IkB kinase gamma subunit, I-kappa-B kinase gamma, IKKG, IkB kinase-associated protein 1, IKKAP1, FIP-3
Molecular Weight 48197 DA
Gene ID 8517
UniProt Q9Y6K9
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Application Notes WB = 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 0.275 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (full length) antibody The anti-IKKgamma Mab (ABIN387828) is used in Western blot to detect IKKgamma in ZR75-1 cell lysate.
Background publications de Jong, Albrecht, Schmidt et al.: "Activation of noncanonical NF-kappaB signaling by the oncoprotein Tio." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 16495-503, 2010 (PubMed).

Ammirante, Rosati, Arra et al.: "IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 16, pp. 7497-502, 2010 (PubMed).

Fusco, DUrso, Miano et al.: "The LCR at the IKBKG locus is prone to recombine." in: American journal of human genetics, Vol. 86, Issue 4, pp. 650-2; author reply 652-3, 2010 (PubMed).

Hsiao, Lin, Chiang et al.: "NEMO gene mutations in Chinese patients with incontinentia pigmenti." in: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 109, Issue 3, pp. 192-200, 2010 (PubMed).

Mooster, Cancrini, Simonetti et al.: "Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 1, pp. 127-32.e7, 2010 (PubMed).

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