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DNMT3A antibody (C-Term)

DNMT3A Reactivity: Human WB Host: Rabbit Polyclonal RB12504 unconjugated
Catalog No. ABIN387865
  • Target See all DNMT3A Antibodies
    DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
    Binding Specificity
    • 16
    • 16
    • 13
    • 12
    • 10
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 723-752, C-Term
    Reactivity
    • 133
    • 50
    • 48
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 124
    • 12
    Rabbit
    Clonality
    • 114
    • 22
    Polyclonal
    Conjugate
    • 58
    • 12
    • 11
    • 11
    • 9
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This DNMT3A antibody is un-conjugated
    Application
    • 106
    • 68
    • 30
    • 27
    • 26
    • 21
    • 13
    • 12
    • 8
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    M, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This Dnmt3A/Dnmt3A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-752 amino acids from the C-terminal region of human Dnmt3A/Dnmt3A2.
    Clone
    RB12504
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DNMT3A Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • ODoherty, OShea, Sandra, Lonergan, Fair, Forde: "Imprinted and DNA methyltransferase gene expression in the endometrium during the pre- and peri-implantation period in cattle." in: Reproduction, fertility, and development, Vol. 29, Issue 9, pp. 1729-1738, (2018) (PubMed).

    ODoherty, OShea, Fair: "Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins." in: Biology of reproduction, Vol. 86, Issue 3, pp. 67, (2012) (PubMed).

  • Target
    DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
    Alternative Name
    Dnmt3A/Dnmt3A2 (DNMT3A Products)
    Synonyms
    DNMT3A antibody, DNMT3A2 antibody, M.HsaIIIA antibody, MmuIIIA antibody, dnmt3a1 antibody, dnmt6 antibody, DNA methyltransferase 3 alpha antibody, DNA methyltransferase 3A antibody, DNA (cytosine-5-)-methyltransferase 3 alpha b antibody, DNMT3A antibody, Dnmt3a antibody, dnmt3a antibody, dnmt3ab antibody
    Background
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3A is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
    Molecular Weight
    101858
    Gene ID
    1788
    NCBI Accession
    NP_072046, NP_715640, NP_783328, NP_783329
    UniProt
    Q9Y6K1
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