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DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (AA 457-486), (Asp472), (Center) antibody

Details for Product No. ABIN387882, Supplier: Log in to see
Antigen
  • DNMT3A
  • DNMT3A2
  • M.HsaIIIA
  • MmuIIIA
Epitope
AA 457-486, Asp472, Center
41
16
15
14
14
12
8
8
7
7
7
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
190
54
35
3
2
2
2
1
1
1
1
1
1
1
1
Host
Rabbit
177
14
2
2
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
11
10
10
7
7
7
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
160
89
48
22
14
11
10
8
6
4
1
Supplier
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Immunogen This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 AA from the Central region of human Dnmt3a.
Clone RB15269
Isotype Ig
Specificity This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465~494 amino acids from the Center region of human DNMT3A.
Predicted Reactivity Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Dnmt3a (DNMT3A Antibody Abstract)
Background CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Synonyms: DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA
Molecular Weight 101558 DA
Gene ID 1788
UniProt Q9Y6K1
Research Area Signaling, Protein Modifications, Transcription Factors, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (AA 457-486), (Asp472), (Center) antibody (ABIN387882) Western blot analysis of anti-DNMT3A Antibody (Center D472) (ABIN387882) in Jurkat ce...
Immunohistochemistry (IHC) image for anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (AA 457-486), (Asp472), (Center) antibody (ABIN387882) Formalin-fixed and paraffin-embedded human kidney tissue reacted with the primary ant...
Product cited in: Chestnut, Chang, Price et al.: "Epigenetic regulation of motor neuron cell death through DNA methylation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 46, pp. 16619-36, 2011 (PubMed).

Background publications Xie, Wang, Okano et al.: "Cloning, expression and chromosome locations of the human DNMT3 gene family." in: Gene, Vol. 236, Issue 1, pp. 87-95, 1999 (PubMed).

Robertson, Uzvolgyi, Liang et al.: "The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors." in: Nucleic acids research, Vol. 27, Issue 11, pp. 2291-8, 1999 (PubMed).