SENP6 antibody (SUMO1/sentrin Specific Protease 6) (AA 1081-1112)

Details for Product anti-SENP6 Antibody No. ABIN388052, Supplier: Log in to see
Antigen
  • 2810017C20Rik
  • E130319N12Rik
  • Susp1
  • mKIAA0797
  • SSP1
  • SUSP1
  • SUMO1/sentrin specific peptidase 6
  • SUMO/sentrin specific peptidase 6
  • SENP6
  • Senp6
Epitope
AA 1081-1112, C-Term
41
36
14
14
4
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
117
16
8
6
5
5
3
3
2
2
2
1
Host
Rabbit
86
30
4
Clonality (Clone)
Polyclonal ()
Conjugate
This SENP6 antibody is un-conjugated
10
10
10
10
10
10
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
92
69
49
14
11
7
2
Options
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Immunogen This SENP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1081-1112 AA from the C-terminal region of human SENP6.
Clone RB0664
Isotype Ig
Specificity This SENP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1083~1112 amino acids from the C-terminal region of human SENP6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SENP6 (SENP6 Antibody Abstract)
Background SENP6 (SUSP1) is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. This protein does not seem to be involved in the processing of full-length SUMO proteins to their mature conjugatable forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.
Synonyms: Sentrin-specific protease 6, Sentrin/SUMO-specific protease SENP6, SUMO-1-specific protease 1, SENP6, KIAA0797, SSP1, SUSP1
Molecular Weight 126144 DA
Gene ID 26054
UniProt Q9GZR1
Research Area Apoptosis/Necrosis, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SENP6 antibody (SUMO1/sentrin Specific Protease 6) (AA 1081-1112) (ABIN388052) Western blot analysis of SENP6 polyclonal antibody (ABIN388052) in HL60 cell lysate. ...
Immunohistochemistry (IHC) image for anti-SENP6 antibody (SUMO1/sentrin Specific Protease 6) (AA 1081-1112) (ABIN388052) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Lee, Lee, Park, Kang, Yoo, Ka, Oh, Jeon, Chung: "SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage." in: The EMBO journal, Vol. 31, Issue 23, pp. 4441-52, 2012 (PubMed).

Jones, Fusi, Higham, Abdel-Hafiz, Horwitz, Lam, Brosens: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, 2006 (PubMed).

Choi, Chung, Rho, Lee, Lee, Choi, Seol, Baek, Bang, Chung: "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1." in: The Journal of biological chemistry, Vol. 281, Issue 41, pp. 30669-77, 2006 (PubMed).

Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Kim, Baek, Jeon, Nishimori, Suzuki, Uchida, Shimbara, Saitoh, Tanaka, Chung: "A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14102-6, 2000 (PubMed).