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SENP6 antibody (C-Term)

SENP6 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB0664 unconjugated
Catalog No. ABIN388052
  • Target See all SENP6 Antibodies
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    Binding Specificity
    • 17
    • 8
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1081-1112, C-Term
    Reactivity
    • 52
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 48
    • 2
    • 2
    Rabbit
    Clonality
    • 50
    • 2
    Polyclonal
    Conjugate
    • 22
    • 6
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SENP6 antibody is un-conjugated
    Application
    • 37
    • 31
    • 24
    • 8
    • 5
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This SENP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1081-1112 amino acids from the C-terminal region of human SENP6.
    Clone
    RB0664
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SENP6 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Lee, Lee, Park, Kang, Yoo, Ka, Oh, Jeon, Chung: "SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage." in: The EMBO journal, Vol. 31, Issue 23, pp. 4441-52, (2012) (PubMed).

    Jones, Fusi, Higham, Abdel-Hafiz, Horwitz, Lam, Brosens: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, (2006) (PubMed).

    Choi, Chung, Rho, Lee, Lee, Choi, Seol, Baek, Bang, Chung: "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1." in: The Journal of biological chemistry, Vol. 281, Issue 41, pp. 30669-77, (2006) (PubMed).

  • Target
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    Alternative Name
    SENP6 (SENP6 Products)
    Synonyms
    SSP1 antibody, SUSP1 antibody, 2810017C20Rik antibody, E130319N12Rik antibody, Susp1 antibody, mKIAA0797 antibody, fc83h02 antibody, im:7148342 antibody, wu:fc83h02 antibody, zgc:171230 antibody, SUMO1/sentrin specific peptidase 6 antibody, SUMO/sentrin specific peptidase 6 antibody, SUMO1/sentrin specific peptidase 6a antibody, SENP6 antibody, Senp6 antibody, senp6a antibody
    Background
    SENP6 (SUSP1) is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. This protein does not seem to be involved in the processing of full-length SUMO proteins to their mature conjugatable forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.
    Molecular Weight
    126146
    Gene ID
    26054
    NCBI Accession
    NP_001093879, NP_056386
    UniProt
    Q9GZR1
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