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CBLC antibody (N-Term)

CBLC Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB0694 unconjugated
Catalog No. ABIN388071
  • Target See all CBLC Antibodies
    CBLC (Cbl proto-oncogene C (CBLC))
    Binding Specificity
    • 10
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivity
    • 46
    • 2
    • 1
    Human
    Host
    • 41
    • 5
    Rabbit
    Clonality
    • 41
    • 5
    Polyclonal
    Conjugate
    • 26
    • 4
    • 4
    • 4
    • 4
    • 4
    This CBLC antibody is un-conjugated
    Application
    • 45
    • 34
    • 29
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CBLC.
    Clone
    RB0694
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CBLC Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    CBLC (Cbl proto-oncogene C (CBLC))
    Alternative Name
    CBLC (CBLC Products)
    Synonyms
    CBL-3 antibody, CBL-SL antibody, RNF57 antibody, Cbl proto-oncogene C antibody, CBLC antibody, Cblc antibody
    Background
    CBLC proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
    Molecular Weight
    52456
    Gene ID
    23624
    NCBI Accession
    NP_001124324, NP_036248
    UniProt
    Q9ULV8
    Pathways
    EGFR Signaling Pathway
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