Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN388071
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Antigen
Synonyms 4732447J05Rik, Cbl-2, c-Cbl, cbl, C-CBL, CBL2, FRA11B, NSLL, RNF55, c-cbl-like, RGD1561386
Epitope
N-Term, AA 1-30
(31), (30), (22), (20), (19), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(224), (139), (136), (62), (50), (50), (24)
Host
Rabbit
(198), (21), (10), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(158), (75), (66), (60), (50), (41), (21), (19), (19), (4), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN388071
291.50 $
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  • +1 404 474 4654
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Immunogen This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human CBLC.
Clone RB0694
Isotype Ig
Specificity This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3~33 amino acids from the N-terminal region of human Cbl-c.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Cbl
Background CBLC proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Synonyms: Signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, RING finger protein 57, RNF57, CBLC
Molecular Weight 52456 DA
Gene ID 23624
UniProt Q9ULV8
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC = 1:50-100, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (N-Term), (AA 1-30) antibody Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (N-Term), (AA 1-30) antibody (2) CBLC Antibody (R10) (ABIN388071) western blot analysis in CEM cell line lysates (35 µg/lane).This demonstrates the CBLC antibody detected the CBLC protein (arrow).
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Validation Images
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