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Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) (AA 93-122), (N-Term) antibody

Details for Product No. ABIN388081, Supplier: Log in to see
Antigen
  • SUV39H2
  • kmt1b
  • KMT1B
  • 4930507K23Rik
  • AA536750
  • D030054H19Rik
  • D2Ertd544e
Epitope
AA 93-122, N-Term
51
20
18
7
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
105
22
12
6
4
3
2
Host
Rabbit
90
15
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
7
7
7
7
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
85
68
33
8
7
7
3
Supplier
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Immunogen This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-122 AA from the N-terminal region of human SUV39H2.
Clone RB02737
Isotype Ig
Specificity This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40~70 amino acids from the N-terminal region of humanSUV39H2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SUV39H2 (SUV39H2 Antibody Abstract)
Background The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
Synonyms: KMT1B
Molecular Weight 46682 DA
Gene ID 79723
NCBI Accession NP_078946
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) (AA 93-122), (N-Term) antibody (ABIN388081) The anti-SUV39H2 Pab (ABIN388081) is used in Western blot to detect SUV39H2 in mouse ...
Immunohistochemistry (IHC) image for anti-Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) (AA 93-122), (N-Term) antibody (ABIN388081) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Chen, Yeh, Yang et al.: "High expressions of histone methylation- and phosphorylation-related proteins are associated with prognosis of oral squamous cell carcinoma in male population of Taiwan." in: Medical oncology (Northwood, London, England), Vol. 30, Issue 2, pp. 513, 2013 (PubMed).

Benlhabib, Mendelson: "Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia." in: Molecular and cellular biology, Vol. 31, Issue 10, pp. 1949-58, 2011 (PubMed).

Background publications Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).