Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) (C-Term), (AA 360-390) antibody

Details for Product No. ABIN388082
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Antigen
Synonyms SUV39H2, kmt1b, KMT1B, 4930507K23Rik, AA536750, D030054H19Rik, D2Ertd544e
Epitope
C-Term, AA 360-390
(20), (10), (10), (9), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(61), (18), (5), (2), (2), (2)
Host
Rabbit
(55), (5), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(56), (41), (15), (6), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN388082
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Immunogen This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-390 AA from the C-terminal region of human SUV39H2.
Clone RB02739
Isotype Ig
Predicted Reactivity Monkey
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SUV39H2
Background The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

Synonyms: KMT1B
Molecular Weight 46682 Da
Gene ID 79723
NCBI Accession NP_078946
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes Suggested dilutions:
WB = 1:1000, IHC = 1:50-100
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months
Supplier Images
anti-Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) (C-Term), (AA 360-390) antibody Western blot analysis of anti-hSUV39H2-K315 Pab (ABIN388082) in 293 and HL60 cell line lysates (35 µg/lane). hSUV39H2-K315(arrow) was detected using the purified polyclonal antibody (1:62 dilution).
anti-Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) (C-Term), (AA 360-390) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Validation Images
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