Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) (C-Term, Lys375) antibody

Antigen: Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2)

Synonyms: KMT1B, AA536750, D2Ertd544e, 4930507K23Rik, D030054H19Rik, FLJ23414, SUV39H2, MGC128675

Binding Site: C-Term, Lys375

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN388084

Additional Information

Alternative name: SUV39H2

Gene ID: 79723

UniProt: Q6I9Y3

Immunogen: This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SUV39H2.

Isotype: Ig

Description: Other names: Suppressor of variegation 3-9 homolog 2,, KMT1B

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SUV39H2.

Molecular Weight: 39946 DA

Comments:

Background: SUV39H2 is a histone methyltransferase that methylates Lys-9 of histone H3 and weakly histone H1 (in vitro). H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. SUV39H2 may participate in regulation of higher order chromatin organization during spermatogenesis.

Application Details

Application Notes: The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Apoptosis/Necrosis, Signaling, Protein Modifications, Transcription Factors, Chromatin, Cell Structure

Restrictions: For Research Use only

Images

Western blot analysis of anti-SUV39H2 Antibody (C-term K375) (ABIN388084) in NIH-3T3 cell line lysates (35ug/lane). SUV39H2 (arrow) was detected using the purified Pab.

Publications

Product: Rea, Eisenhaber, OCarroll et al.: "Regulation of chromatin structure by site-specific histone H3 methyltransferases." in: Nature, Vol. 406, Issue 6796, pp. 593-9, 2000 (PubMed).

OCarroll, Scherthan, Peters et al.: "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression." in: Molecular and cellular biology, Vol. 20, Issue 24, pp. 9423-33, 2000 (PubMed).