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SUMO2 antibody (SMT3 Suppressor of Mif Two 3 Homolog 2 (S. Cerevisiae)) (AA 63-93)

Details for Product anti-SUMO2 Antibody No. ABIN388085, Supplier: Log in to see
Antigen
  • ATSUMO2
  • HSMT3
  • hsmt3
  • MCO15.11
  • MCO15_11
  • PSMT3
  • SMALL UBIQUITIN-LIKE MODIFIER 2
  • small ubiquitin-like modifier 2
  • SMT3A
  • Smt3A
  • SMT3B
  • Smt3B
  • Smt3b
  • smt3b
  • SMT3H1
  • Smt3h2
  • SMT3H2
  • smt3h2
  • SUM2
  • SUMO-2
  • sumo-2
  • SUMO-3
  • SUMO2
  • sumo2
  • SUMO 2
  • SUMO3
  • zgc:92241
Epitope
AA 63-93, C-Term
47
33
10
10
7
7
5
5
4
2
2
2
1
1
1
1
1
Reactivity
Human
203
78
26
12
3
1
1
1
1
Host
Rabbit
138
75
2
Clonality (Clone)
Polyclonal ()
Conjugate
This SUMO2 antibody is un-conjugated
12
11
11
11
9
9
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
125
102
75
51
50
32
6
4
2
1
1
Supplier
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Immunogen This SUMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-93 AA from the C-terminal region of human SUMO2.
Clone RB2761
Isotype Ig
Specificity This SUMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SUMO2.
Predicted Reactivity Cow (Bovine),Chicken,Hamster,Mouse (Murine),Pig (Porcine),Monkey,Rat (Rattus),Xenopus laevis,Zebrafish
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SUMO2 (SUMO2 Antibody Abstract)
Background SUMO2 is a member of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
Synonyms: Small ubiquitin-related modifier 2, SUMO-2, Ubiquitin-like protein SMT3B, SMT3 homolog 2, Sentrin-2, HSMT3, SUMO-3, SMT3B, SMT3H2
Molecular Weight 11637 DA
Gene ID 6613
UniProt P61956
Research Area Apoptosis/Necrosis, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes IHC (p) = 1:50-100, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-SUMO2 antibody (SMT3 Suppressor of Mif Two 3 Homolog 2 (S. Cerevisiae)) (AA 63-93) (ABIN388085) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-SUMO2 antibody (SMT3 Suppressor of Mif Two 3 Homolog 2 (S. Cerevisiae)) (AA 63-93) (ABIN388085) The SUMO2 C-term Antibody (ABIN388085) is used in Western blot to detect SUMO2 in GST...
Western Blotting (WB) image for anti-SUMO2 antibody (SMT3 Suppressor of Mif Two 3 Homolog 2 (S. Cerevisiae)) (AA 63-93) (ABIN388085) Western blot analysis of SUMO2 (arrow) using rabbit polyclonal SUMO2 Antibody (ABIN38...
Product cited in: Mori, Tanji, Odagiri, Hattori, Hoshikawa, Kono, Yasui, Yokoi, Hasegawa, Kamitani, Yoshida, Wakabayashi: "Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease." in: Pathology international, Vol. 62, Issue 6, pp. 407-11, 2012 (PubMed).

Mori, Miki, Tanji, Ogura, Yagihashi, Jensen, Wakabayashi: "Incipient intranuclear inclusion body disease in a 78-year-old woman." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 31, Issue 2, pp. 188-93, 2011 (PubMed).

Janer, Werner, Takahashi-Fujigasaki, Daret, Fujigasaki, Takada, Duyckaerts, Brice, Dejean, Sittler: "SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7." in: Human molecular genetics, Vol. 19, Issue 1, pp. 181-95, 2009 (PubMed).

Zhang, Sarge: "Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies." in: The Journal of cell biology, Vol. 182, Issue 1, pp. 35-9, 2008 (PubMed).

Background publications Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Lapenta, Chiurazzi, van der Spek, Pizzuti, Hanaoka, Brahe: "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family." in: Genomics, Vol. 40, Issue 2, pp. 362-6, 1997 (PubMed).