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B Cell Leukemia/lymphoma 2 Related Protein A1a (BCL2A1A) (AA 30-65), (BH3 Domain) antibody

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Antigen
Epitope
AA 30-65, BH3 Domain
Reactivity
Human
1
Host
Rabbit
1
Clonality (Clone)
Polyclonal ()
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1
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Immunogen This BCL2A1 (A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-65 AA from human BCL2A1 (A1).
Clone RB1251
Isotype Ig
Specificity This BCL2A1 (A1) antibody was developed against a synthetic peptide selected from the N-terminal region of human BCL2-related protein A1, within the BH3 domain.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name BCL2A1 (A1)
Background Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
Synonyms: Human Bcl2-related Protein A1, BFL1, Hematopoietic-specific early response protein, GRS protein
Molecular Weight 20132 DA
Gene ID 597
UniProt Q16548
Research Area Apoptosis/Necrosis, Cancer, Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.71 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-B Cell Leukemia/lymphoma 2 Related Protein A1a (BCL2A1A) (AA 30-65), (BH3 Domain) antibody (ABIN388092) Western blot analysis of anti-Bcl2-related Protein A1 Pab (ABIN388092) in human place...
Immunohistochemistry (IHC) image for anti-B Cell Leukemia/lymphoma 2 Related Protein A1a (BCL2A1A) (AA 30-65), (BH3 Domain) antibody (ABIN388092) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Gollob, Sciambi, Huang et al.: "Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma." in: Cancer research, Vol. 65, Issue 19, pp. 8869-77, 2005 (PubMed).

Background publications Deng, Gao, May: "Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding." in: Blood, Vol. 113, Issue 2, pp. 422-8, 2009 (PubMed).

Akatsuka, Nishida, Kondo et al.: "Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens." in: The Journal of experimental medicine, Vol. 197, Issue 11, pp. 1489-500, 2003 (PubMed).

Akari, Bour, Kao et al.: "The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors." in: The Journal of experimental medicine, Vol. 194, Issue 9, pp. 1299-311, 2001 (PubMed).